Clinical Features and Surveillance of Very Late Hepatocellular Carcinoma Recurrence After Liver Transplantation
BACKGROUND This study aimed to assess patterns of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and to establish long-term surveillance protocols for late HCC recurrence. MATERIAL AND METHODS The 232 LT recipients experiencing subsequent HCC recurrence were categorized a...
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| Veröffentlicht in: | Annals of Transplantation 2018-09, Vol.23, p.659-665 |
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| container_title | Annals of Transplantation |
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| creator | Alshahrani, Abdulwahab A Ha, Su-Min Hwang, Shin Ahn, Chul-Soo Kim, Ki-Hun Moon, Deok-Bog Ha, Tae-Yong Song, Gi-Won Jung, Dong-Hwan Park, Gil-Chun Cho, Hwi-Dong Kwon, Jae Hyun Kang, Sang-Hyun Lee, Sung-Gyu |
| description | BACKGROUND This study aimed to assess patterns of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and to establish long-term surveillance protocols for late HCC recurrence. MATERIAL AND METHODS The 232 LT recipients experiencing subsequent HCC recurrence were categorized as Group 1, early recurrence (within 1 year of LT; n=117); Group 2, late recurrence (occurring in years 2-5; n=93); and Group 3, very late recurrence (after year 5; n=22). RESULTS Recurrence was detected by only elevated tumor marker levels in 11.1%, 30.1%, and 45.5% of patients in Groups 1, 2, and 3, respectively (p |
| doi_str_mv | 10.12659/AOT.910598 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6255332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>30237389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-ab2d6b0b8ca4f1bb5a9122dab1e3c90cf46745aa61b9e4e52359fd2a7bc9c9cd3</originalsourceid><addsrcrecordid>eNpVkNFLwzAQxoMoTuaefJe8S2eTNF3zIozhnFAY6PS1XNKrBrK2pOlg_73V6Zgc3B3c9_0OPkJuWDxlPJXqfr7eTBWLpcrOyBUXXEWxkNn5yT4ik66zOk44V4xJeUlGIuZiJjJ1RZqFs7U14OgSIfQeOwp1SV97v0PrHNQGaVPRd_R7mkNAusIWQmPQud6BpwvwxtbNFugLmt57_DbMq4Ce5nY39I2HumsHUIBgm_qaXFTgOpz8zjF5Wz5uFqsoXz89L-Z5ZETGQgSal6mOdWYgqZjWEhTjvATNUBgVmypJZ4kESJlWmKDkQqqq5DDTRg1VijF5OHDbXm-xNFgHD65ovd2C3xcN2OL_pbafxUezK1IupRB8ANwdAMY3XeexOnpZXPxEXwzRF4foB_Xt6buj9i9o8QUz7YL8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Clinical Features and Surveillance of Very Late Hepatocellular Carcinoma Recurrence After Liver Transplantation</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Alshahrani, Abdulwahab A ; Ha, Su-Min ; Hwang, Shin ; Ahn, Chul-Soo ; Kim, Ki-Hun ; Moon, Deok-Bog ; Ha, Tae-Yong ; Song, Gi-Won ; Jung, Dong-Hwan ; Park, Gil-Chun ; Cho, Hwi-Dong ; Kwon, Jae Hyun ; Kang, Sang-Hyun ; Lee, Sung-Gyu</creator><creatorcontrib>Alshahrani, Abdulwahab A ; Ha, Su-Min ; Hwang, Shin ; Ahn, Chul-Soo ; Kim, Ki-Hun ; Moon, Deok-Bog ; Ha, Tae-Yong ; Song, Gi-Won ; Jung, Dong-Hwan ; Park, Gil-Chun ; Cho, Hwi-Dong ; Kwon, Jae Hyun ; Kang, Sang-Hyun ; Lee, Sung-Gyu</creatorcontrib><description>BACKGROUND This study aimed to assess patterns of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and to establish long-term surveillance protocols for late HCC recurrence. MATERIAL AND METHODS The 232 LT recipients experiencing subsequent HCC recurrence were categorized as Group 1, early recurrence (within 1 year of LT; n=117); Group 2, late recurrence (occurring in years 2-5; n=93); and Group 3, very late recurrence (after year 5; n=22). RESULTS Recurrence was detected by only elevated tumor marker levels in 11.1%, 30.1%, and 45.5% of patients in Groups 1, 2, and 3, respectively (p<0.001). The proportion of intrahepatic and extrahepatic metastases was similar in all 3 groups. Common sites of extrahepatic metastasis were the lung and bone; these were also similar across the 3 groups. Overall post-recurrence patient survival rates were 60.2% at 1 year, 28.2% at 3 years, 20.5% at 5 years, and 7.0% at 10 years. Median post-recurrence survival periods were 10.2, 23.8, and 37.0 months in Groups 1, 2, and 3, respectively. CONCLUSIONS While the pattern of HCC recurrence was similar regardless of time of recurrence, post-recurrence survival was significantly longer in patients with later recurrence. Long-term surveillance for HCC recurrence beyond 5 years after LT is recommended.</description><identifier>ISSN: 2329-0358</identifier><identifier>ISSN: 1425-9524</identifier><identifier>EISSN: 2329-0358</identifier><identifier>DOI: 10.12659/AOT.910598</identifier><identifier>PMID: 30237389</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Aged ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Female ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation ; Male ; Middle Aged ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Original Paper ; Survival Rate ; Treatment Outcome</subject><ispartof>Annals of Transplantation, 2018-09, Vol.23, p.659-665</ispartof><rights>Ann Transplant, 2018 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-ab2d6b0b8ca4f1bb5a9122dab1e3c90cf46745aa61b9e4e52359fd2a7bc9c9cd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255332/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255332/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30237389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alshahrani, Abdulwahab A</creatorcontrib><creatorcontrib>Ha, Su-Min</creatorcontrib><creatorcontrib>Hwang, Shin</creatorcontrib><creatorcontrib>Ahn, Chul-Soo</creatorcontrib><creatorcontrib>Kim, Ki-Hun</creatorcontrib><creatorcontrib>Moon, Deok-Bog</creatorcontrib><creatorcontrib>Ha, Tae-Yong</creatorcontrib><creatorcontrib>Song, Gi-Won</creatorcontrib><creatorcontrib>Jung, Dong-Hwan</creatorcontrib><creatorcontrib>Park, Gil-Chun</creatorcontrib><creatorcontrib>Cho, Hwi-Dong</creatorcontrib><creatorcontrib>Kwon, Jae Hyun</creatorcontrib><creatorcontrib>Kang, Sang-Hyun</creatorcontrib><creatorcontrib>Lee, Sung-Gyu</creatorcontrib><title>Clinical Features and Surveillance of Very Late Hepatocellular Carcinoma Recurrence After Liver Transplantation</title><title>Annals of Transplantation</title><addtitle>Ann Transplant</addtitle><description>BACKGROUND This study aimed to assess patterns of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and to establish long-term surveillance protocols for late HCC recurrence. MATERIAL AND METHODS The 232 LT recipients experiencing subsequent HCC recurrence were categorized as Group 1, early recurrence (within 1 year of LT; n=117); Group 2, late recurrence (occurring in years 2-5; n=93); and Group 3, very late recurrence (after year 5; n=22). RESULTS Recurrence was detected by only elevated tumor marker levels in 11.1%, 30.1%, and 45.5% of patients in Groups 1, 2, and 3, respectively (p<0.001). The proportion of intrahepatic and extrahepatic metastases was similar in all 3 groups. Common sites of extrahepatic metastasis were the lung and bone; these were also similar across the 3 groups. Overall post-recurrence patient survival rates were 60.2% at 1 year, 28.2% at 3 years, 20.5% at 5 years, and 7.0% at 10 years. Median post-recurrence survival periods were 10.2, 23.8, and 37.0 months in Groups 1, 2, and 3, respectively. CONCLUSIONS While the pattern of HCC recurrence was similar regardless of time of recurrence, post-recurrence survival was significantly longer in patients with later recurrence. Long-term surveillance for HCC recurrence beyond 5 years after LT is recommended.</description><subject>Aged</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Original Paper</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>2329-0358</issn><issn>1425-9524</issn><issn>2329-0358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkNFLwzAQxoMoTuaefJe8S2eTNF3zIozhnFAY6PS1XNKrBrK2pOlg_73V6Zgc3B3c9_0OPkJuWDxlPJXqfr7eTBWLpcrOyBUXXEWxkNn5yT4ik66zOk44V4xJeUlGIuZiJjJ1RZqFs7U14OgSIfQeOwp1SV97v0PrHNQGaVPRd_R7mkNAusIWQmPQud6BpwvwxtbNFugLmt57_DbMq4Ce5nY39I2HumsHUIBgm_qaXFTgOpz8zjF5Wz5uFqsoXz89L-Z5ZETGQgSal6mOdWYgqZjWEhTjvATNUBgVmypJZ4kESJlWmKDkQqqq5DDTRg1VijF5OHDbXm-xNFgHD65ovd2C3xcN2OL_pbafxUezK1IupRB8ANwdAMY3XeexOnpZXPxEXwzRF4foB_Xt6buj9i9o8QUz7YL8</recordid><startdate>20180921</startdate><enddate>20180921</enddate><creator>Alshahrani, Abdulwahab A</creator><creator>Ha, Su-Min</creator><creator>Hwang, Shin</creator><creator>Ahn, Chul-Soo</creator><creator>Kim, Ki-Hun</creator><creator>Moon, Deok-Bog</creator><creator>Ha, Tae-Yong</creator><creator>Song, Gi-Won</creator><creator>Jung, Dong-Hwan</creator><creator>Park, Gil-Chun</creator><creator>Cho, Hwi-Dong</creator><creator>Kwon, Jae Hyun</creator><creator>Kang, Sang-Hyun</creator><creator>Lee, Sung-Gyu</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20180921</creationdate><title>Clinical Features and Surveillance of Very Late Hepatocellular Carcinoma Recurrence After Liver Transplantation</title><author>Alshahrani, Abdulwahab A ; Ha, Su-Min ; Hwang, Shin ; Ahn, Chul-Soo ; Kim, Ki-Hun ; Moon, Deok-Bog ; Ha, Tae-Yong ; Song, Gi-Won ; Jung, Dong-Hwan ; Park, Gil-Chun ; Cho, Hwi-Dong ; Kwon, Jae Hyun ; Kang, Sang-Hyun ; Lee, Sung-Gyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-ab2d6b0b8ca4f1bb5a9122dab1e3c90cf46745aa61b9e4e52359fd2a7bc9c9cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Original Paper</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Alshahrani, Abdulwahab A</creatorcontrib><creatorcontrib>Ha, Su-Min</creatorcontrib><creatorcontrib>Hwang, Shin</creatorcontrib><creatorcontrib>Ahn, Chul-Soo</creatorcontrib><creatorcontrib>Kim, Ki-Hun</creatorcontrib><creatorcontrib>Moon, Deok-Bog</creatorcontrib><creatorcontrib>Ha, Tae-Yong</creatorcontrib><creatorcontrib>Song, Gi-Won</creatorcontrib><creatorcontrib>Jung, Dong-Hwan</creatorcontrib><creatorcontrib>Park, Gil-Chun</creatorcontrib><creatorcontrib>Cho, Hwi-Dong</creatorcontrib><creatorcontrib>Kwon, Jae Hyun</creatorcontrib><creatorcontrib>Kang, Sang-Hyun</creatorcontrib><creatorcontrib>Lee, Sung-Gyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alshahrani, Abdulwahab A</au><au>Ha, Su-Min</au><au>Hwang, Shin</au><au>Ahn, Chul-Soo</au><au>Kim, Ki-Hun</au><au>Moon, Deok-Bog</au><au>Ha, Tae-Yong</au><au>Song, Gi-Won</au><au>Jung, Dong-Hwan</au><au>Park, Gil-Chun</au><au>Cho, Hwi-Dong</au><au>Kwon, Jae Hyun</au><au>Kang, Sang-Hyun</au><au>Lee, Sung-Gyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Features and Surveillance of Very Late Hepatocellular Carcinoma Recurrence After Liver Transplantation</atitle><jtitle>Annals of Transplantation</jtitle><addtitle>Ann Transplant</addtitle><date>2018-09-21</date><risdate>2018</risdate><volume>23</volume><spage>659</spage><epage>665</epage><pages>659-665</pages><issn>2329-0358</issn><issn>1425-9524</issn><eissn>2329-0358</eissn><abstract>BACKGROUND This study aimed to assess patterns of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and to establish long-term surveillance protocols for late HCC recurrence. MATERIAL AND METHODS The 232 LT recipients experiencing subsequent HCC recurrence were categorized as Group 1, early recurrence (within 1 year of LT; n=117); Group 2, late recurrence (occurring in years 2-5; n=93); and Group 3, very late recurrence (after year 5; n=22). RESULTS Recurrence was detected by only elevated tumor marker levels in 11.1%, 30.1%, and 45.5% of patients in Groups 1, 2, and 3, respectively (p<0.001). The proportion of intrahepatic and extrahepatic metastases was similar in all 3 groups. Common sites of extrahepatic metastasis were the lung and bone; these were also similar across the 3 groups. Overall post-recurrence patient survival rates were 60.2% at 1 year, 28.2% at 3 years, 20.5% at 5 years, and 7.0% at 10 years. Median post-recurrence survival periods were 10.2, 23.8, and 37.0 months in Groups 1, 2, and 3, respectively. CONCLUSIONS While the pattern of HCC recurrence was similar regardless of time of recurrence, post-recurrence survival was significantly longer in patients with later recurrence. Long-term surveillance for HCC recurrence beyond 5 years after LT is recommended.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>30237389</pmid><doi>10.12659/AOT.910598</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Female Humans Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation Male Middle Aged Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Original Paper Survival Rate Treatment Outcome |
| title | Clinical Features and Surveillance of Very Late Hepatocellular Carcinoma Recurrence After Liver Transplantation |
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