Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice

Protein phosphatase 5 (PP5), a serine/threonine phosphatase, has a wide range of biological functions and exhibits elevated expression in tumor cells. We previously reported that pp5-deficient mice have altered ataxia-telangiectasia mutated (ATM)-mediated signaling and function. However, this regula...

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Veröffentlicht in:	The Journal of biological chemistry 2018-11, Vol.293 (47), p.18218-18229
Hauptverfasser:	Wang, Jun, Shen, Tao, Zhu, Wuqiang, Dou, Longyu, Gu, Hao, Zhang, Lingling, Yang, Zhenyun, Chen, Hanying, Zhou, Qi, Sánchez, Edwin R., Field, Loren J., Mayo, Lindsey D., Xie, Zhongwen, Xiao, Deyong, Lin, Xia, Shou, Weinian, Yong, Weidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Cell Biology Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Damage Down-Regulation Mice Mice, Inbred C57BL Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphoprotein Phosphatases - chemistry Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - metabolism Promoter Regions, Genetic Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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