Hypoxia-induced brain cell damage in male albino wistar rat
The biochemical markers of rat under low oxygen concentration, including brain water level, lactic acid, necrosis and Na+-K+-ATPase, was detected to analyze the hypoxia-induced brain damage, and to analyze the mechanism of brain injury. Histopathological alteration in brain tissue induced by hypoxia...
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| Veröffentlicht in: | Saudi journal of biological sciences 2018-11, Vol.25 (7), p.1473-1477 |
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| container_title | Saudi journal of biological sciences |
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| creator | Liu, Hongtao Zhang, HuiJuan Niu, Xiaolin Li, Siyuan Zheng, Simin Xiong, Hongfei Lv, Junlin |
| description | The biochemical markers of rat under low oxygen concentration, including brain water level, lactic acid,
necrosis and Na+-K+-ATPase, was detected to analyze the hypoxia-induced brain damage, and to analyze
the mechanism of brain injury. Histopathological alteration in brain tissue induced by hypoxia were
investigated through hematoxylin and eosin stain (HE). Hypoxia induced factor-1a (HIF-1a) expression
level in the brain was carried out using immunohistochemistry. Lactic acid level was positively correlated
with the level of hypoxia, while concentration-dependent decrease in total Na+-K+-ATPase activity was
noted. Hypoxia induced rathad a significant difference on brain water content compared to controls. The
level of necrosis and lactic acid level was increased, and the decrease of Na+-K+-ATPase activity was
observed. Histopathological examination of brain confirmed that there was neuronal cell death in hippocampal
region. HIF-1a expression increased the hypoxia adaptation capability of the rat through the
expressions of genes. Lactic acid, Na+-K+-ATPase and HIF-1a plays an important role in brain injury. |
| doi_str_mv | 10.1016/j.sjbs.2017.03.018 |
| format | Article |
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necrosis and Na+-K+-ATPase, was detected to analyze the hypoxia-induced brain damage, and to analyze
the mechanism of brain injury. Histopathological alteration in brain tissue induced by hypoxia were
investigated through hematoxylin and eosin stain (HE). Hypoxia induced factor-1a (HIF-1a) expression
level in the brain was carried out using immunohistochemistry. Lactic acid level was positively correlated
with the level of hypoxia, while concentration-dependent decrease in total Na+-K+-ATPase activity was
noted. Hypoxia induced rathad a significant difference on brain water content compared to controls. The
level of necrosis and lactic acid level was increased, and the decrease of Na+-K+-ATPase activity was
observed. Histopathological examination of brain confirmed that there was neuronal cell death in hippocampal
region. HIF-1a expression increased the hypoxia adaptation capability of the rat through the
expressions of genes. Lactic acid, Na+-K+-ATPase and HIF-1a plays an important role in brain injury.</description><identifier>ISSN: 1319-562X</identifier><identifier>EISSN: 2213-7106</identifier><identifier>DOI: 10.1016/j.sjbs.2017.03.018</identifier><identifier>PMID: 30505197</identifier><language>eng</language><publisher>Riyadh, Saudi Arabia: Saudi Biological Society</publisher><subject>التعبير الجيني ; الجرذان ; الكيمياء الحيوية ; تلف الدماغ ; نقص التأكسج</subject><ispartof>Saudi journal of biological sciences, 2018-11, Vol.25 (7), p.1473-1477</ispartof><rights>2017 The Authors 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-9622b6a9323ac28266454885c8f98a3c2a7e0b805def710951273dd27a43cdb23</citedby><cites>FETCH-LOGICAL-c424t-9622b6a9323ac28266454885c8f98a3c2a7e0b805def710951273dd27a43cdb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252012/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252012/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30505197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Hongtao</creatorcontrib><creatorcontrib>Zhang, HuiJuan</creatorcontrib><creatorcontrib>Niu, Xiaolin</creatorcontrib><creatorcontrib>Li, Siyuan</creatorcontrib><creatorcontrib>Zheng, Simin</creatorcontrib><creatorcontrib>Xiong, Hongfei</creatorcontrib><creatorcontrib>Lv, Junlin</creatorcontrib><title>Hypoxia-induced brain cell damage in male albino wistar rat</title><title>Saudi journal of biological sciences</title><addtitle>Saudi J Biol Sci</addtitle><description>The biochemical markers of rat under low oxygen concentration, including brain water level, lactic acid,
necrosis and Na+-K+-ATPase, was detected to analyze the hypoxia-induced brain damage, and to analyze
the mechanism of brain injury. Histopathological alteration in brain tissue induced by hypoxia were
investigated through hematoxylin and eosin stain (HE). Hypoxia induced factor-1a (HIF-1a) expression
level in the brain was carried out using immunohistochemistry. Lactic acid level was positively correlated
with the level of hypoxia, while concentration-dependent decrease in total Na+-K+-ATPase activity was
noted. Hypoxia induced rathad a significant difference on brain water content compared to controls. The
level of necrosis and lactic acid level was increased, and the decrease of Na+-K+-ATPase activity was
observed. Histopathological examination of brain confirmed that there was neuronal cell death in hippocampal
region. HIF-1a expression increased the hypoxia adaptation capability of the rat through the
expressions of genes. Lactic acid, Na+-K+-ATPase and HIF-1a plays an important role in brain injury.</description><subject>التعبير الجيني</subject><subject>الجرذان</subject><subject>الكيمياء الحيوية</subject><subject>تلف الدماغ</subject><subject>نقص التأكسج</subject><issn>1319-562X</issn><issn>2213-7106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVkNtKxDAQhoMouh5eQFB66U1rMjk0RRBEPIHgjYJ3YZqmmqWHNel6eHtbVhe9CpN882fmI-SQ0YxRpk7nWZyXMQPK8ozyjDK9QWYAjKc5o2qTzBhnRSoVPO-Q3RjnlCrNNdsmO5xKKlmRz8jZ7dei__SY-q5aWlclZUDfJdY1TVJhiy8uGcsWG5dgU_quTz58HDAkAYd9slVjE93Bz7lHnq6vHi9v0_uHm7vLi_vUChBDWiiAUmHBgaMFDUoJKbSWVteFRm4Bc0dLTWXl6nHwQjLIeVVBjoLbqgS-R85XuYtl2brKum4I2JhF8C2GL9OjN_9fOv9qXvp3o0COcqaAk5-A0L8tXRxM6-O0InauX0YDTBSUSiHEiMIKtaGPMbh6_Q2jZrJu5maybibrhnIzWh-bjv8OuG751TwCRyvAjfeuxjWhi5xJyb8BOv6IeQ</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Liu, Hongtao</creator><creator>Zhang, HuiJuan</creator><creator>Niu, Xiaolin</creator><creator>Li, Siyuan</creator><creator>Zheng, Simin</creator><creator>Xiong, Hongfei</creator><creator>Lv, Junlin</creator><general>Saudi Biological Society</general><general>Elsevier</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>Hypoxia-induced brain cell damage in male albino wistar rat</title><author>Liu, Hongtao ; Zhang, HuiJuan ; Niu, Xiaolin ; Li, Siyuan ; Zheng, Simin ; Xiong, Hongfei ; Lv, Junlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-9622b6a9323ac28266454885c8f98a3c2a7e0b805def710951273dd27a43cdb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>التعبير الجيني</topic><topic>الجرذان</topic><topic>الكيمياء الحيوية</topic><topic>تلف الدماغ</topic><topic>نقص التأكسج</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Hongtao</creatorcontrib><creatorcontrib>Zhang, HuiJuan</creatorcontrib><creatorcontrib>Niu, Xiaolin</creatorcontrib><creatorcontrib>Li, Siyuan</creatorcontrib><creatorcontrib>Zheng, Simin</creatorcontrib><creatorcontrib>Xiong, Hongfei</creatorcontrib><creatorcontrib>Lv, Junlin</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Saudi journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Hongtao</au><au>Zhang, HuiJuan</au><au>Niu, Xiaolin</au><au>Li, Siyuan</au><au>Zheng, Simin</au><au>Xiong, Hongfei</au><au>Lv, Junlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxia-induced brain cell damage in male albino wistar rat</atitle><jtitle>Saudi journal of biological sciences</jtitle><addtitle>Saudi J Biol Sci</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>25</volume><issue>7</issue><spage>1473</spage><epage>1477</epage><pages>1473-1477</pages><issn>1319-562X</issn><eissn>2213-7106</eissn><abstract>The biochemical markers of rat under low oxygen concentration, including brain water level, lactic acid,
necrosis and Na+-K+-ATPase, was detected to analyze the hypoxia-induced brain damage, and to analyze
the mechanism of brain injury. Histopathological alteration in brain tissue induced by hypoxia were
investigated through hematoxylin and eosin stain (HE). Hypoxia induced factor-1a (HIF-1a) expression
level in the brain was carried out using immunohistochemistry. Lactic acid level was positively correlated
with the level of hypoxia, while concentration-dependent decrease in total Na+-K+-ATPase activity was
noted. Hypoxia induced rathad a significant difference on brain water content compared to controls. The
level of necrosis and lactic acid level was increased, and the decrease of Na+-K+-ATPase activity was
observed. Histopathological examination of brain confirmed that there was neuronal cell death in hippocampal
region. HIF-1a expression increased the hypoxia adaptation capability of the rat through the
expressions of genes. Lactic acid, Na+-K+-ATPase and HIF-1a plays an important role in brain injury.</abstract><cop>Riyadh, Saudi Arabia</cop><pub>Saudi Biological Society</pub><pmid>30505197</pmid><doi>10.1016/j.sjbs.2017.03.018</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Saudi journal of biological sciences, 2018-11, Vol.25 (7), p.1473-1477 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6252012 |
| source | Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | التعبير الجيني الجرذان الكيمياء الحيوية تلف الدماغ نقص التأكسج |
| title | Hypoxia-induced brain cell damage in male albino wistar rat |
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