Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a neuromuscular disease that predominantly affects boys as a result of mutation(s) in the dystrophin gene. DMD is characterized by musculoskeletal and cardiopulmonary complications, resulting in shorter life-span. Boys afflicted by DMD typically exhibit symptoms...

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Veröffentlicht in:	Human molecular genetics 2017-07, Vol.26 (13), p.2526-2540
Hauptverfasser:	Ponnusamy, Suriyan, Sullivan, Ryan D, You, Dahui, Zafar, Nadeem, He Yang, Chuan, Thiyagarajan, Thirumagal, Johnson, Daniel L, Barrett, Maron L, Koehler, Nikki J, Star, Mayra, Stephenson, Erin J, Bridges, Dave, Cormier, Stephania A, Pfeffer, Lawrence M, Narayanan, Ramesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - genetics Androgens - metabolism Animals Disease Models, Animal Dystrophin - genetics Fibrosis Male Mice Mice, Inbred mdx Muscle Weakness - metabolism Muscle, Skeletal - metabolism Muscular Dystrophy, Animal - genetics Muscular Dystrophy, Duchenne - genetics Muscular Dystrophy, Duchenne - metabolism Receptors, Androgen - metabolism Sexual Maturation Utrophin - genetics
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