Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats
Gut microbiota dysbiosis has been linked to obesity-associated chronic inflammation. Microbiota manipulation may therefore affect obesity-related comorbidities. Blueberries are rich in anthocyanins, which have anti-inflammatory properties and may alter the gut microbiota. We hypothesized that bluebe...
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| creator | Lee, Sunhye Keirsey, Katherine I Kirkland, Rebecca Grunewald, Zachary I Fischer, Joan G de La Serre, Claire B |
| description | Gut microbiota dysbiosis has been linked to obesity-associated chronic inflammation. Microbiota manipulation may therefore affect obesity-related comorbidities. Blueberries are rich in anthocyanins, which have anti-inflammatory properties and may alter the gut microbiota.
We hypothesized that blueberry supplementation would alter the gut microbiota, reduce systemic inflammation, and improve insulin resistance in high-fat (HF)-diet-fed rats.
Twenty-four male Wistar rats (260-270 g; n = 8/group) were fed low-fat (LF; 10% fat), HF (45% fat), or HF with 10% by weight blueberry powder (HF_BB) diets for 8 wk. LF rats were fed ad libitum, whereas HF and HF_BB rats were pair-fed with diets matched for fiber and sugar contents. Glucose tolerance, microbiota composition (16S ribosomal RNA sequencing), intestinal integrity [villus height, gene expression of mucin 2 (Muc2) and β-defensin 2 (Defb2)], and inflammation (gene expression of proinflammatory cytokines) were assessed.
Blueberry altered microbiota composition with an increase in Gammaproteobacteria abundance (P < 0.001) compared with LF and HF rats. HF feeding led to an ∼15% decrease in ileal villus height compared with LF rats (P < 0.05), which was restored by blueberry supplementation. Ileal gene expression of Muc2 was ∼150% higher in HF_BB rats compared with HF rats (P < 0.05), with expression in the LF group not being different from that in either the HF or HF_BB groups. Tumor necrosis factor α (Tnfa) and interleukin 1β (Il1b) gene expression in visceral fat was increased by HF feeding when compared with the LF group (by 300% and 500%, respectively; P < 0.05) and normalized by blueberry supplementation. Finally, blueberry improved markers of insulin sensitivity. Hepatic insulin receptor substrate 1 (IRS1) phosphorylation at serine 307:IRS1 ratio was ∼35% higher in HF rats compared with LF rats (P < 0.05) and HF_BB rats.
In HF-diet-fed male rats, blueberry supplementation led to compositional changes in the gut microbiota associated with improvements in systemic inflammation and insulin signaling. |
| doi_str_mv | 10.1093/jn/nxx027 |
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We hypothesized that blueberry supplementation would alter the gut microbiota, reduce systemic inflammation, and improve insulin resistance in high-fat (HF)-diet-fed rats.
Twenty-four male Wistar rats (260-270 g; n = 8/group) were fed low-fat (LF; 10% fat), HF (45% fat), or HF with 10% by weight blueberry powder (HF_BB) diets for 8 wk. LF rats were fed ad libitum, whereas HF and HF_BB rats were pair-fed with diets matched for fiber and sugar contents. Glucose tolerance, microbiota composition (16S ribosomal RNA sequencing), intestinal integrity [villus height, gene expression of mucin 2 (Muc2) and β-defensin 2 (Defb2)], and inflammation (gene expression of proinflammatory cytokines) were assessed.
Blueberry altered microbiota composition with an increase in Gammaproteobacteria abundance (P < 0.001) compared with LF and HF rats. HF feeding led to an ∼15% decrease in ileal villus height compared with LF rats (P < 0.05), which was restored by blueberry supplementation. Ileal gene expression of Muc2 was ∼150% higher in HF_BB rats compared with HF rats (P < 0.05), with expression in the LF group not being different from that in either the HF or HF_BB groups. Tumor necrosis factor α (Tnfa) and interleukin 1β (Il1b) gene expression in visceral fat was increased by HF feeding when compared with the LF group (by 300% and 500%, respectively; P < 0.05) and normalized by blueberry supplementation. Finally, blueberry improved markers of insulin sensitivity. Hepatic insulin receptor substrate 1 (IRS1) phosphorylation at serine 307:IRS1 ratio was ∼35% higher in HF rats compared with LF rats (P < 0.05) and HF_BB rats.
In HF-diet-fed male rats, blueberry supplementation led to compositional changes in the gut microbiota associated with improvements in systemic inflammation and insulin signaling.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/nxx027</identifier><identifier>PMID: 29490092</identifier><language>eng</language><publisher>United States: American Institute of Nutrition</publisher><subject>Adipose Tissue - drug effects ; Animals ; Anthocyanins ; Anthocyanins - administration & dosage ; Anti-inflammatory agents ; Bacteria - classification ; Berries ; Blueberries ; Blueberry Plants ; Cytokines ; Diet ; Diet, High-Fat - adverse effects ; Dietary Fiber - administration & dosage ; Dietary Supplements ; Digestive system ; DNA, Bacterial - analysis ; Dysbacteriosis ; Feeding ; Fruit - chemistry ; Fruits ; Gastrointestinal Microbiome - drug effects ; Gastrointestinal Microbiome - genetics ; Gastrointestinal tract ; Gene expression ; Gene sequencing ; Glucose tolerance ; Glucose Tolerance Test ; High fat diet ; Inflammation ; Inflammation - prevention & control ; Insulin ; Insulin receptor substrate 1 ; Insulin resistance ; Insulin Resistance - physiology ; Interleukin 1 ; Intestine ; Liver - drug effects ; Male ; Mucin ; Nutrition and Disease ; Obesity ; Phosphorylation ; Plant Extracts - administration & dosage ; Powder ; Rats ; Rats, Wistar ; Ribonucleic acid ; RNA ; Rodents ; rRNA 16S ; Sequence Analysis, DNA ; Serine ; Substrates ; Sugar ; Villus</subject><ispartof>The Journal of nutrition, 2018-02, Vol.148 (2), p.209-219</ispartof><rights>Copyright American Institute of Nutrition Feb 2018</rights><rights>2018 American Society for Nutrition. All rights reserved 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-dc1d68371778e1107afda6712f3062f352660aaee1fc5293679d4cc7442df1c53</citedby><cites>FETCH-LOGICAL-c403t-dc1d68371778e1107afda6712f3062f352660aaee1fc5293679d4cc7442df1c53</cites><orcidid>0000-0001-8355-6087</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29490092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sunhye</creatorcontrib><creatorcontrib>Keirsey, Katherine I</creatorcontrib><creatorcontrib>Kirkland, Rebecca</creatorcontrib><creatorcontrib>Grunewald, Zachary I</creatorcontrib><creatorcontrib>Fischer, Joan G</creatorcontrib><creatorcontrib>de La Serre, Claire B</creatorcontrib><title>Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Gut microbiota dysbiosis has been linked to obesity-associated chronic inflammation. Microbiota manipulation may therefore affect obesity-related comorbidities. Blueberries are rich in anthocyanins, which have anti-inflammatory properties and may alter the gut microbiota.
We hypothesized that blueberry supplementation would alter the gut microbiota, reduce systemic inflammation, and improve insulin resistance in high-fat (HF)-diet-fed rats.
Twenty-four male Wistar rats (260-270 g; n = 8/group) were fed low-fat (LF; 10% fat), HF (45% fat), or HF with 10% by weight blueberry powder (HF_BB) diets for 8 wk. LF rats were fed ad libitum, whereas HF and HF_BB rats were pair-fed with diets matched for fiber and sugar contents. Glucose tolerance, microbiota composition (16S ribosomal RNA sequencing), intestinal integrity [villus height, gene expression of mucin 2 (Muc2) and β-defensin 2 (Defb2)], and inflammation (gene expression of proinflammatory cytokines) were assessed.
Blueberry altered microbiota composition with an increase in Gammaproteobacteria abundance (P < 0.001) compared with LF and HF rats. HF feeding led to an ∼15% decrease in ileal villus height compared with LF rats (P < 0.05), which was restored by blueberry supplementation. Ileal gene expression of Muc2 was ∼150% higher in HF_BB rats compared with HF rats (P < 0.05), with expression in the LF group not being different from that in either the HF or HF_BB groups. Tumor necrosis factor α (Tnfa) and interleukin 1β (Il1b) gene expression in visceral fat was increased by HF feeding when compared with the LF group (by 300% and 500%, respectively; P < 0.05) and normalized by blueberry supplementation. Finally, blueberry improved markers of insulin sensitivity. Hepatic insulin receptor substrate 1 (IRS1) phosphorylation at serine 307:IRS1 ratio was ∼35% higher in HF rats compared with LF rats (P < 0.05) and HF_BB rats.
In HF-diet-fed male rats, blueberry supplementation led to compositional changes in the gut microbiota associated with improvements in systemic inflammation and insulin signaling.</description><subject>Adipose Tissue - drug effects</subject><subject>Animals</subject><subject>Anthocyanins</subject><subject>Anthocyanins - administration & dosage</subject><subject>Anti-inflammatory agents</subject><subject>Bacteria - classification</subject><subject>Berries</subject><subject>Blueberries</subject><subject>Blueberry Plants</subject><subject>Cytokines</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Dietary Supplements</subject><subject>Digestive system</subject><subject>DNA, Bacterial - analysis</subject><subject>Dysbacteriosis</subject><subject>Feeding</subject><subject>Fruit - chemistry</subject><subject>Fruits</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gastrointestinal Microbiome - genetics</subject><subject>Gastrointestinal tract</subject><subject>Gene expression</subject><subject>Gene sequencing</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>High fat diet</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>Insulin</subject><subject>Insulin receptor substrate 1</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Interleukin 1</subject><subject>Intestine</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>Mucin</subject><subject>Nutrition and Disease</subject><subject>Obesity</subject><subject>Phosphorylation</subject><subject>Plant Extracts - administration & dosage</subject><subject>Powder</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Rodents</subject><subject>rRNA 16S</subject><subject>Sequence Analysis, DNA</subject><subject>Serine</subject><subject>Substrates</subject><subject>Sugar</subject><subject>Villus</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVFPFDEUhRsjkRV98A-YJr5owshtO9NuX0wUWSDBkIA-N93OHbabmc7SdhT-vYUFIr60ac_X23PvIeQdg88MtDhYh4NwcwNcvSAz1tSskgzgJZkBcF4JJuUueZ3SGgBYreevyC7XtQbQfEb-fOsnXGKMt_Ry2mx6HDBkm_0Y6GnoihYcJppXSI-nTH94F8elH7Pdv5ftMNyz-9SGttykqfeBXmDyKdvykpbTib9aVQubq-8ec7XAll7YnN6Qnc72Cd8-7Hvk1-Lo5-FJdXZ-fHr49axyNYhctY61ci4UU2qOjIGyXWulYrwTIMvScCnBWkTWuYZrIZVua-dUXfO2Y64Re-TLtu5mWg7YutJdtL3ZRD_YeGtG681zJfiVuRp_G8kbJpUsBT4-FIjj9YQpm8Enh31vA45TMrzMsZFaw91fH_5D1-MUQ2mvUIIJXbxCoT5tqTLKlCJ2T2YYmLs4zTqYbZyFff-v-yfyMT_xFwJFnME</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Lee, Sunhye</creator><creator>Keirsey, Katherine I</creator><creator>Kirkland, Rebecca</creator><creator>Grunewald, Zachary I</creator><creator>Fischer, Joan G</creator><creator>de La Serre, Claire B</creator><general>American Institute of Nutrition</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8355-6087</orcidid></search><sort><creationdate>20180201</creationdate><title>Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats</title><author>Lee, Sunhye ; Keirsey, Katherine I ; Kirkland, Rebecca ; Grunewald, Zachary I ; Fischer, Joan G ; de La Serre, Claire B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-dc1d68371778e1107afda6712f3062f352660aaee1fc5293679d4cc7442df1c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose Tissue - drug effects</topic><topic>Animals</topic><topic>Anthocyanins</topic><topic>Anthocyanins - administration & dosage</topic><topic>Anti-inflammatory agents</topic><topic>Bacteria - classification</topic><topic>Berries</topic><topic>Blueberries</topic><topic>Blueberry Plants</topic><topic>Cytokines</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Dietary Supplements</topic><topic>Digestive system</topic><topic>DNA, Bacterial - analysis</topic><topic>Dysbacteriosis</topic><topic>Feeding</topic><topic>Fruit - chemistry</topic><topic>Fruits</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gastrointestinal Microbiome - genetics</topic><topic>Gastrointestinal tract</topic><topic>Gene expression</topic><topic>Gene sequencing</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>High fat diet</topic><topic>Inflammation</topic><topic>Inflammation - prevention & control</topic><topic>Insulin</topic><topic>Insulin receptor substrate 1</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Interleukin 1</topic><topic>Intestine</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>Mucin</topic><topic>Nutrition and Disease</topic><topic>Obesity</topic><topic>Phosphorylation</topic><topic>Plant Extracts - administration & dosage</topic><topic>Powder</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Rodents</topic><topic>rRNA 16S</topic><topic>Sequence Analysis, DNA</topic><topic>Serine</topic><topic>Substrates</topic><topic>Sugar</topic><topic>Villus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sunhye</creatorcontrib><creatorcontrib>Keirsey, Katherine I</creatorcontrib><creatorcontrib>Kirkland, Rebecca</creatorcontrib><creatorcontrib>Grunewald, Zachary I</creatorcontrib><creatorcontrib>Fischer, Joan G</creatorcontrib><creatorcontrib>de La Serre, Claire B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sunhye</au><au>Keirsey, Katherine I</au><au>Kirkland, Rebecca</au><au>Grunewald, Zachary I</au><au>Fischer, Joan G</au><au>de La Serre, Claire B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>148</volume><issue>2</issue><spage>209</spage><epage>219</epage><pages>209-219</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Gut microbiota dysbiosis has been linked to obesity-associated chronic inflammation. Microbiota manipulation may therefore affect obesity-related comorbidities. Blueberries are rich in anthocyanins, which have anti-inflammatory properties and may alter the gut microbiota.
We hypothesized that blueberry supplementation would alter the gut microbiota, reduce systemic inflammation, and improve insulin resistance in high-fat (HF)-diet-fed rats.
Twenty-four male Wistar rats (260-270 g; n = 8/group) were fed low-fat (LF; 10% fat), HF (45% fat), or HF with 10% by weight blueberry powder (HF_BB) diets for 8 wk. LF rats were fed ad libitum, whereas HF and HF_BB rats were pair-fed with diets matched for fiber and sugar contents. Glucose tolerance, microbiota composition (16S ribosomal RNA sequencing), intestinal integrity [villus height, gene expression of mucin 2 (Muc2) and β-defensin 2 (Defb2)], and inflammation (gene expression of proinflammatory cytokines) were assessed.
Blueberry altered microbiota composition with an increase in Gammaproteobacteria abundance (P < 0.001) compared with LF and HF rats. HF feeding led to an ∼15% decrease in ileal villus height compared with LF rats (P < 0.05), which was restored by blueberry supplementation. Ileal gene expression of Muc2 was ∼150% higher in HF_BB rats compared with HF rats (P < 0.05), with expression in the LF group not being different from that in either the HF or HF_BB groups. Tumor necrosis factor α (Tnfa) and interleukin 1β (Il1b) gene expression in visceral fat was increased by HF feeding when compared with the LF group (by 300% and 500%, respectively; P < 0.05) and normalized by blueberry supplementation. Finally, blueberry improved markers of insulin sensitivity. Hepatic insulin receptor substrate 1 (IRS1) phosphorylation at serine 307:IRS1 ratio was ∼35% higher in HF rats compared with LF rats (P < 0.05) and HF_BB rats.
In HF-diet-fed male rats, blueberry supplementation led to compositional changes in the gut microbiota associated with improvements in systemic inflammation and insulin signaling.</abstract><cop>United States</cop><pub>American Institute of Nutrition</pub><pmid>29490092</pmid><doi>10.1093/jn/nxx027</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8355-6087</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - drug effects Animals Anthocyanins Anthocyanins - administration & dosage Anti-inflammatory agents Bacteria - classification Berries Blueberries Blueberry Plants Cytokines Diet Diet, High-Fat - adverse effects Dietary Fiber - administration & dosage Dietary Supplements Digestive system DNA, Bacterial - analysis Dysbacteriosis Feeding Fruit - chemistry Fruits Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - genetics Gastrointestinal tract Gene expression Gene sequencing Glucose tolerance Glucose Tolerance Test High fat diet Inflammation Inflammation - prevention & control Insulin Insulin receptor substrate 1 Insulin resistance Insulin Resistance - physiology Interleukin 1 Intestine Liver - drug effects Male Mucin Nutrition and Disease Obesity Phosphorylation Plant Extracts - administration & dosage Powder Rats Rats, Wistar Ribonucleic acid RNA Rodents rRNA 16S Sequence Analysis, DNA Serine Substrates Sugar Villus |
| title | Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats |
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