Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases
The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of th...
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| Veröffentlicht in: | Disease markers 2018-01, Vol.2018 (2018), p.1-22 |
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| creator | García-García, Abel Alonso-Sampedro, Manuela García-Vence, María Lopez Jornet, Pia Bravo, Susana B. Pérez-Sayáns, Mario Lorenzo-Pouso, Alejandro I. Carballo, Javier |
| description | The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches. |
| doi_str_mv | 10.1155/2018/6141845 |
| format | Article |
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Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2018/6141845</identifier><identifier>PMID: 30524521</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aprotinin ; Bioindicators ; Biological markers ; Biology ; Biomarkers ; Biomarkers - metabolism ; Dental caries ; Diseases ; Enzymes ; Ethylenediaminetetraacetic acid ; Humans ; Medical research ; Molecular biology ; Mouth Diseases - diagnosis ; Mouth Diseases - metabolism ; Oral cancer ; Oral diseases ; Peptides ; Peptides - analysis ; Periodontal disease ; Periodontal Diseases - diagnosis ; Periodontal Diseases - metabolism ; Periodontics ; Physiology ; Population ; Proteins ; Proteins - analysis ; Proteomics ; Proteomics - methods ; Review ; Saliva ; Saliva - metabolism ; Tooth Diseases - diagnosis ; Tooth Diseases - metabolism</subject><ispartof>Disease markers, 2018-01, Vol.2018 (2018), p.1-22</ispartof><rights>Copyright © 2018 Alejandro I. Lorenzo-Pouso et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Alejandro I. Lorenzo-Pouso et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Alejandro I. Lorenzo-Pouso et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-ad3809460c74153b17c159fbb607478c69ceae8897cf7d0c1432e1d4038d732e3</citedby><cites>FETCH-LOGICAL-c565t-ad3809460c74153b17c159fbb607478c69ceae8897cf7d0c1432e1d4038d732e3</cites><orcidid>0000-0002-3314-8613 ; 0000-0002-9180-4703</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247606/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247606/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30524521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zalewska, Anna</contributor><creatorcontrib>García-García, Abel</creatorcontrib><creatorcontrib>Alonso-Sampedro, Manuela</creatorcontrib><creatorcontrib>García-Vence, María</creatorcontrib><creatorcontrib>Lopez Jornet, Pia</creatorcontrib><creatorcontrib>Bravo, Susana B.</creatorcontrib><creatorcontrib>Pérez-Sayáns, Mario</creatorcontrib><creatorcontrib>Lorenzo-Pouso, Alejandro I.</creatorcontrib><creatorcontrib>Carballo, Javier</creatorcontrib><title>Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. 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This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.</description><subject>Aprotinin</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Dental caries</subject><subject>Diseases</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Humans</subject><subject>Medical research</subject><subject>Molecular biology</subject><subject>Mouth Diseases - diagnosis</subject><subject>Mouth Diseases - metabolism</subject><subject>Oral cancer</subject><subject>Oral diseases</subject><subject>Peptides</subject><subject>Peptides - analysis</subject><subject>Periodontal disease</subject><subject>Periodontal Diseases - diagnosis</subject><subject>Periodontal Diseases - metabolism</subject><subject>Periodontics</subject><subject>Physiology</subject><subject>Population</subject><subject>Proteins</subject><subject>Proteins - analysis</subject><subject>Proteomics</subject><subject>Proteomics - methods</subject><subject>Review</subject><subject>Saliva</subject><subject>Saliva - metabolism</subject><subject>Tooth Diseases - diagnosis</subject><subject>Tooth Diseases - metabolism</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc1vEzEQxS0EomnhxhmtxAUJlo6_vRektpQPqaJIwNlyvLOty2Zd7CRV_3smSiiFEydbnp_fvJnH2DMObzjX-lAAd4eGK-6UfsBm3FndOiPhIZuBsK4FoWCP7dd6BcBFp7rHbE-CFkoLPmOnX0peYpra41Cxb76GMa1DuW3oeUgj1ibU5nNe49gcp7wI5QeW2gy5NOcljM27VJH-1Sfs0RDGik935wH7_v7028nH9uz8w6eTo7M2aqOXbeilg04ZiFZxLefcRq67YT43YJV10XQRAzrX2TjYHiJXUiDvFUjXW7rKA_Z2q3u9mi-wjzgtyYa_Loms3fockv-7MqVLf5HX3ghlDRgSeLkTKPnnCuvSL1KNOI5hwryqXtBGqT-AIvTFP-hVXpWJxiNKalqrFfeoizCiT9OQqW_ciPoj7azZyAmiXm-pWHKtBYc7yxz8JkW_SdHvUiT8-f0x7-DfsRHwagtcpqkPN-k_5ZAYHMIfmkJQnZK_ADocq8A</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>García-García, Abel</creator><creator>Alonso-Sampedro, Manuela</creator><creator>García-Vence, María</creator><creator>Lopez Jornet, Pia</creator><creator>Bravo, Susana B.</creator><creator>Pérez-Sayáns, Mario</creator><creator>Lorenzo-Pouso, Alejandro I.</creator><creator>Carballo, Javier</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3314-8613</orcidid><orcidid>https://orcid.org/0000-0002-9180-4703</orcidid></search><sort><creationdate>20180101</creationdate><title>Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases</title><author>García-García, Abel ; Alonso-Sampedro, Manuela ; García-Vence, María ; Lopez Jornet, Pia ; Bravo, Susana B. ; Pérez-Sayáns, Mario ; Lorenzo-Pouso, Alejandro I. ; Carballo, Javier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-ad3809460c74153b17c159fbb607478c69ceae8897cf7d0c1432e1d4038d732e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aprotinin</topic><topic>Bioindicators</topic><topic>Biological markers</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Dental caries</topic><topic>Diseases</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Humans</topic><topic>Medical research</topic><topic>Molecular biology</topic><topic>Mouth Diseases - diagnosis</topic><topic>Mouth Diseases - metabolism</topic><topic>Oral cancer</topic><topic>Oral diseases</topic><topic>Peptides</topic><topic>Peptides - analysis</topic><topic>Periodontal disease</topic><topic>Periodontal Diseases - diagnosis</topic><topic>Periodontal Diseases - metabolism</topic><topic>Periodontics</topic><topic>Physiology</topic><topic>Population</topic><topic>Proteins</topic><topic>Proteins - analysis</topic><topic>Proteomics</topic><topic>Proteomics - methods</topic><topic>Review</topic><topic>Saliva</topic><topic>Saliva - metabolism</topic><topic>Tooth Diseases - diagnosis</topic><topic>Tooth Diseases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-García, Abel</creatorcontrib><creatorcontrib>Alonso-Sampedro, Manuela</creatorcontrib><creatorcontrib>García-Vence, María</creatorcontrib><creatorcontrib>Lopez Jornet, Pia</creatorcontrib><creatorcontrib>Bravo, Susana B.</creatorcontrib><creatorcontrib>Pérez-Sayáns, Mario</creatorcontrib><creatorcontrib>Lorenzo-Pouso, Alejandro I.</creatorcontrib><creatorcontrib>Carballo, Javier</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-García, Abel</au><au>Alonso-Sampedro, Manuela</au><au>García-Vence, María</au><au>Lopez Jornet, Pia</au><au>Bravo, Susana B.</au><au>Pérez-Sayáns, Mario</au><au>Lorenzo-Pouso, Alejandro I.</au><au>Carballo, Javier</au><au>Zalewska, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>22</epage><pages>1-22</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30524521</pmid><doi>10.1155/2018/6141845</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-3314-8613</orcidid><orcidid>https://orcid.org/0000-0002-9180-4703</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aprotinin Bioindicators Biological markers Biology Biomarkers Biomarkers - metabolism Dental caries Diseases Enzymes Ethylenediaminetetraacetic acid Humans Medical research Molecular biology Mouth Diseases - diagnosis Mouth Diseases - metabolism Oral cancer Oral diseases Peptides Peptides - analysis Periodontal disease Periodontal Diseases - diagnosis Periodontal Diseases - metabolism Periodontics Physiology Population Proteins Proteins - analysis Proteomics Proteomics - methods Review Saliva Saliva - metabolism Tooth Diseases - diagnosis Tooth Diseases - metabolism |
| title | Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases |
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