Combination Immune Checkpoint Blockade Strategies to Maximize Immune Response in Gynecological Cancers

Purpose of Review Immune checkpoint blockade targeting PD-1 and PD-L1 improves immune recognition of tumor cells but had only modest success in gynecological cancers as monotherapy. Growing focus has been placed on combination immunotherapy strategies to overcome this resistance, and this review ser...

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Veröffentlicht in:	Current oncology reports 2018-12, Vol.20 (12), p.94-94, Article 94
Hauptverfasser:	Liu, Ying L., Zamarin, Dmitriy
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antineoplastic Agents, Immunological - classification Antineoplastic Agents, Immunological - therapeutic use Cell Cycle Checkpoints - drug effects Cervical cancer Chemotherapy CTLA-4 protein Endometrial cancer Female Genital Neoplasms, Female - drug therapy Genital Neoplasms, Female - immunology Gynecologic Cancers (NS Reed Gynecologic Cancers (NS Reed, Section Editor) Gynecological cancer Gynecology Humans Immune checkpoint Immune response Immunotherapy Medicine Medicine & Public Health Molecular Targeted Therapy Oncology Ovarian cancer PD-1 protein PD-L1 protein Poly(ADP-ribose) polymerase Prognosis Section Editor Topical Collection on Gynecologic Cancers Tumor cells
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