Absorption, Distribution, Metabolism, and Excretion of the Novel Helicase-Primase Inhibitor, Amenamevir (ASP2151), in Rodents

Background and Objectives The helicase-primase inhibitor amenamevir (ASP2151) is a novel therapeutic agent which has been approved for the treatment of herpes zoster. The present study examined the pharmacokinetic profile of amenamevir in rodents and compared it with data from the literature of past...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 2018-12, Vol.43 (6), p.693-706
Hauptverfasser:	Ohtsu, Yoshiaki, Susaki, Yoko, Noguchi, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - blood Acyclovir - pharmacokinetics Animals Biological Availability Biomedical and Life Sciences Biomedicine Carbon Radioisotopes - pharmacokinetics Human Physiology Male Medical Biochemistry Mice Original Original Research Article Oxadiazoles - blood Oxadiazoles - pharmacokinetics Pharmaceutical Sciences/Technology Pharmacology/Toxicology Pharmacy Rats Tissue Distribution Valacyclovir - blood Valacyclovir - pharmacokinetics
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