DEMENTIA DUE TO ALZHEIMER’S DISEASE AND BRAIN MORPHOMETRIC ALTERATIONS

DEMENTIA DUE TO ALZHEIMER’S DISEASE AND BRAIN MORPHOMETRIC ALTERATIONS

Introduction: Dementia due Alzheimer’s disease (DAD) is a primary and progressive neurodegenerative disorder. There are atrophy in hippocampus and other basal areas. This work evaluated the brain morphometry of DAD patients in all disease stages, aiming at identifying the structural neuro-degenerati...

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Veröffentlicht in:Innovation in aging 2017-07, Vol.1 (suppl_1), p.350-350
Hauptverfasser: Moriguti, J.C., Silva Filho, S.R., Santos, A.C., Ferriolli, E., Lima, N.K.
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container_issue suppl_1
container_start_page 350
container_title Innovation in aging
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creator Moriguti, J.C.
Silva Filho, S.R.
Santos, A.C.
Ferriolli, E.
Lima, N.K.
description Introduction: Dementia due Alzheimer’s disease (DAD) is a primary and progressive neurodegenerative disorder. There are atrophy in hippocampus and other basal areas. This work evaluated the brain morphometry of DAD patients in all disease stages, aiming at identifying the structural neuro-degeneration profile in every phase. Methods: DAD patients above 60 years old (n=44) and age paired controls (n=16) were recruited. The brain images acquired in Achieva 3T magnetic resonance tomograph. Volumetric quantitative data and cortical thickness measurements were obtained by automatic segmentation using Freesurfer®. The volume of each region was normalized considering whole brain volume. Results: Brain regions targeted by the disease during the initial stages were found to be altered until in the later stages of the dementia. No correlation was observed between brain cortical volume or thickness, age and years of education. We found an association between cortical volume or thickness and cognitive indexes Mini Mental State Examination (R 2
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We found an association between cortical volume or thickness and cognitive indexes Mini Mental State Examination (R 2 &lt;0.47), Clinical Dementia Rating and disease duration in years (R 2 &lt;0.52). Conclusion: The most affected brain regions suffer atrophy in a linear fashion until the later stages of the disease, what seems contrary to the hypothesized models, which consider a faster degeneration in earlier stages. These regions are closely related to neuronal loss and gliosis. The cortical thickness measurements were less sensible in differentiating the groups than cortical volume, what may be due to the fact that cortical thickness is more dependent of segmentation quality. 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title DEMENTIA DUE TO ALZHEIMER’S DISEASE AND BRAIN MORPHOMETRIC ALTERATIONS
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