IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages

The goal of cancer immunotherapy is to stimulate the host immune system to attack malignant cells. Antibody-dependent cellular cytotoxicity (ADCC) is a pivotal mechanism of antitumor action of clinically employed antitumor antibodies. IL-15 administered to patients with metastatic malignancy by cont...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-11, Vol.115 (46), p.E10915-E10924
Hauptverfasser:	Zhang, Meili, Wen, Bernard, Anton, Olga M., Yao, Zhengsheng, Dubois, Sigrid, Ju, Wei, Sato, Noriko, DiLillo, David J., Bamford, Richard N., Ravetch, Jeffrey V., Waldmann, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult T cell leukemia Animal models Antitumor activity Biological Sciences Cancer Cancer immunotherapy CD20 antigen Cell activation Cells Clinical trials Cytokines Cytotoxicity Effectors Immune system Immunotherapy Interleukin 15 Leukemia Lymphocytes Lymphocytes T Lymphoma Macrophages Malignancy Medical research Metastases Monoclonal antibodies Natural killer cells PNAS Plus Rituximab Targeted cancer therapy Toxicity Tumors Xenografts Xenotransplantation
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