Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer

The emergence of mutations that confer resistance to molecularly targeted therapeutics is dependent upon the effect of each mutation on drug affinity for the target protein, the clonal fitness of cells harboring the mutation, and the probability that each variant can be generated by DNA codon base m...

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Veröffentlicht in:	Cell chemical biology 2018-11, Vol.25 (11), p.1359-1371.e2
Hauptverfasser:	Kaserer, Teresa, Blagg, Julian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology DNA Mutational Analysis Drug Resistance, Neoplasm Humans Mitogen-Activated Protein Kinase 1 - genetics Models, Molecular Molecular Targeted Therapy Mutation - drug effects Neoplasms - drug therapy Neoplasms - genetics Small Molecule Libraries - pharmacology Software Workflow
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