Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones

Purpose Previously, compounds containing a piperidone structure have been shown to be highly cytotoxic to cancer cells. Recently, we found that the piperidone compound P2 exhibits a potent anti-neoplastic activity against human breast cancer-derived cells. Here, we aimed to evaluate two piperidone c...

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Veröffentlicht in:	Cellular oncology (Dordrecht) 2018-12, Vol.41 (6), p.623-636
Hauptverfasser:	Contreras, Lisett, Calderon, Ruben I., Varela-Ramirez, Armando, Zhang, Hong-Yu, Quan, Yuan, Das, Umashankar, Dimmock, Jonathan R., Skouta, Rachid, Aguilera, Renato J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Caspase Caspase-3 Cell Line, Tumor Cytotoxicity Depolarization Gene expression Gene Expression Profiling Gene Expression Regulation, Leukemic - drug effects Gene Ontology Humans Inhibitory Concentration 50 Leukemia Leukemia - pathology Lymphoma Lymphoma - pathology Membrane potential Mitochondria Molecular Weight Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology Original Paper Pathology Piperidones - chemistry Piperidones - pharmacology Polyubiquitin - metabolism Proteasome Endopeptidase Complex - metabolism Proteasome inhibitors Proteasome Inhibitors - pharmacology Protein folding Reproducibility of Results Signal Transduction - drug effects Ubiquitinated Proteins - metabolism Unfolded Protein Response - drug effects Up-Regulation - drug effects Western blotting
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