Ex vivo induction of regulatory T cells from conventional CD4+ T cells is sensitive to substrate rigidity

The immune system maintains a balance between protection and tolerance. Regulatory T cells (Tregs) function as a vital tolerance mechanism in the immune system to suppress effector immune cells. Additionally, Tregs can be utilized as a form of immunotherapy for autoimmune disorders. As T cells have...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of biomedical materials research. Part A 2018-12, Vol.106 (12), p.3001-3008
Hauptverfasser:	Nataraj, Neha M., Dang, Alex P., Kam, Lance C., Lee, Jounghyun H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Immobilized - chemistry Antibodies, Immobilized - immunology Autoimmune diseases Biocompatible Materials - chemistry CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology Cells, Cultured Contractility Dimethylpolysiloxanes - chemistry Effector cells Elastic Modulus Immune system Immunological tolerance Immunoregulation Immunotherapy Lymphocyte Activation Lymphocytes Lymphocytes T Mechanosensing Mechanotransduction, Cellular Mice Molecular modelling Myosin poly(dimethylsiloxane) Polydimethylsiloxane regulatory T cells Rigidity substrate rigidity Substrates T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T‐cell immunotherapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!