Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro

Background and Purpose Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate and adaptive immune responses. There are several existing therapies for AD, including topical glucocorticosteroids, emollients, phototherapies, calcineurin inhibitors and immunosuppre...

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Veröffentlicht in:	British journal of pharmacology 2018-12, Vol.175 (23), p.4310-4324
Hauptverfasser:	An, Hyun‐Jin, Kim, Jung‐Yeon, Kim, Woon‐Hae, Gwon, Mi‐Gyeong, Gu, Hye Min, Jeon, Min Ji, Han, Sang‐Mi, Pak, Sok Cheon, Lee, Chong‐Kee, Park, In Sook, Park, Kwan‐Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animal models Animals Atopic dermatitis Bee Venoms - pharmacology Bees Calcineurin Calcineurin inhibitors CCL17 protein CCL22 protein Cell Differentiation - drug effects Cell Survival - drug effects Cells, Cultured Chemokines Cyclosporins Dermatitis Dermatitis, Atopic - drug therapy Dermatitis, Atopic - pathology Dinitrobenzene Disease Models, Animal Dose-Response Relationship, Drug Eczema Emollients Female Ginseng Humans Immune response Immunosuppressive agents In Vitro Techniques Inflammation Interferon Keratinocytes Lesions Melitten - pharmacology Mice Mice, Inbred BALB C Research Paper Research Papers Side effects Signal transduction Skin diseases Structure-Activity Relationship Tumor necrosis factor Venom
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