3′‐Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis

Background and Purpose 3′‐Sialyllactose (3′‐SL) is a safe compound that is present in high levels in human milk. Although it has anti‐inflammatory properties and supports immune homeostasis, its effect on collagen‐induced arthritis (CIA) is unknown. In this study, we investigated the prophylactic an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2018-12, Vol.175 (23), p.4295-4309
Hauptverfasser:	Kang, Li‐Jung, Kwon, Eun‐Soo, Lee, Kwang Min, Cho, Chanmi, Lee, Jae‐In, Ryu, Young Bae, Youm, Tae Hyun, Jeon, Jimin, Cho, Mi Ra, Jeong, Seon‐Yong, Lee, Sang‐Rae, Kim, Wook, Yang, Siyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Ankle Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoantibodies Breast milk Cartilage Cell proliferation Cells, Cultured Chemical compounds Chemokines Collagen Cytokines Enzyme-linked immunosorbent assay Homeostasis Immunohistochemistry Inflammation Joint diseases Knee Male Mice Mice, Inbred C57BL Mice, Inbred DBA Oligosaccharides - pharmacology Osteoclastogenesis Phosphorylation Phosphorylation - drug effects Research Paper Research Papers Rheumatoid arthritis Secretion Serum levels Signal transduction Synoviocytes Synovitis Transcription Factor RelA - antagonists & inhibitors Transcription Factor RelA - metabolism Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!