Living Donor Liver Transplant as Rescue Surgery for a Patient with Hepatocellular Carcinoma Who Underwent Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS)
BACKGROUND The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an important tool to induce fast liver hypertrophy. The degree of hepatic fibrosis/cirrhosis in patients with HCC negatively impacts their health, and the risk of liver failure is always present. In...
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| Veröffentlicht in: | The American journal of case reports 2018-11, Vol.19, p.1338-1341 |
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| creator | Fernandes, Eduardo de Souza Martins de Mello, Felipe Pedreira Tavares Andrade, Ronaldo Oliveira Girao, Camila Liberato Pimentel, Leandro Savattone Cesar, Camilla Sousa, Claudia Cristina Brito-Azevedo, Anderson Basto, Samanta Teixeira Torres, Orlando Jorge Martins |
| description | BACKGROUND The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an important tool to induce fast liver hypertrophy. The degree of hepatic fibrosis/cirrhosis in patients with HCC negatively impacts their health, and the risk of liver failure is always present. In these cases, liver transplantation may be necessary as a rescue procedure. We present the case of a patient with HCC who underwent ALPPS and developed liver failure. A living donor liver transplant was performed as a rescue procedure. CASE REPORT A 49-year-old man with chronic hepatitis B without cirrhosis underwent computed tomography, which revealed an expansive lesion in the right lobe of his liver that was diagnosed as hepatocellular carcinoma. Liver resection was indicated and liver cirrhosis was observed with high portal pressure after transection. The treatment strategy was switched from right hepatectomy to ALPPS. The patient developed severe liver dysfunction and liver transplantation was indicated. His postoperative course was uneventful and 3 months after the procedure the patient was without complications. CONCLUSIONS Living donor liver transplantation may be necessary as a rescue procedure for patients who underwent ALPPS and develop liver dysfunction. |
| doi_str_mv | 10.12659/AJCR.911694 |
| format | Article |
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The degree of hepatic fibrosis/cirrhosis in patients with HCC negatively impacts their health, and the risk of liver failure is always present. In these cases, liver transplantation may be necessary as a rescue procedure. We present the case of a patient with HCC who underwent ALPPS and developed liver failure. A living donor liver transplant was performed as a rescue procedure. CASE REPORT A 49-year-old man with chronic hepatitis B without cirrhosis underwent computed tomography, which revealed an expansive lesion in the right lobe of his liver that was diagnosed as hepatocellular carcinoma. Liver resection was indicated and liver cirrhosis was observed with high portal pressure after transection. The treatment strategy was switched from right hepatectomy to ALPPS. The patient developed severe liver dysfunction and liver transplantation was indicated. His postoperative course was uneventful and 3 months after the procedure the patient was without complications. CONCLUSIONS Living donor liver transplantation may be necessary as a rescue procedure for patients who underwent ALPPS and develop liver dysfunction.</description><identifier>ISSN: 1941-5923</identifier><identifier>EISSN: 1941-5923</identifier><identifier>DOI: 10.12659/AJCR.911694</identifier><identifier>PMID: 30409960</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Hepatectomy - methods ; Hepatitis B, Chronic - complications ; Hepatitis B, Chronic - diagnosis ; Hepatitis B, Chronic - surgery ; Humans ; Ligation - methods ; Liver Cirrhosis - pathology ; Liver Cirrhosis - surgery ; Liver Cirrhosis - virology ; Liver Failure - etiology ; Liver Failure - physiopathology ; Liver Failure - surgery ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation - methods ; Living Donors ; Male ; Middle Aged ; Portal Vein - surgery ; Prognosis ; Risk Assessment ; Salvage Therapy ; Treatment Outcome</subject><ispartof>The American journal of case reports, 2018-11, Vol.19, p.1338-1341</ispartof><rights>Am J Case Rep, 2018 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-1705e469022f6fc1df67014c5c812f63393ed2c4f680f762510a5105128174ff3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238545/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238545/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30409960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandes, Eduardo de Souza Martins</creatorcontrib><creatorcontrib>de Mello, Felipe Pedreira Tavares</creatorcontrib><creatorcontrib>Andrade, Ronaldo Oliveira</creatorcontrib><creatorcontrib>Girao, Camila Liberato</creatorcontrib><creatorcontrib>Pimentel, Leandro Savattone</creatorcontrib><creatorcontrib>Cesar, Camilla</creatorcontrib><creatorcontrib>Sousa, Claudia Cristina</creatorcontrib><creatorcontrib>Brito-Azevedo, Anderson</creatorcontrib><creatorcontrib>Basto, Samanta Teixeira</creatorcontrib><creatorcontrib>Torres, Orlando Jorge Martins</creatorcontrib><title>Living Donor Liver Transplant as Rescue Surgery for a Patient with Hepatocellular Carcinoma Who Underwent Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS)</title><title>The American journal of case reports</title><addtitle>Am J Case Rep</addtitle><description>BACKGROUND The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an important tool to induce fast liver hypertrophy. The degree of hepatic fibrosis/cirrhosis in patients with HCC negatively impacts their health, and the risk of liver failure is always present. In these cases, liver transplantation may be necessary as a rescue procedure. We present the case of a patient with HCC who underwent ALPPS and developed liver failure. A living donor liver transplant was performed as a rescue procedure. CASE REPORT A 49-year-old man with chronic hepatitis B without cirrhosis underwent computed tomography, which revealed an expansive lesion in the right lobe of his liver that was diagnosed as hepatocellular carcinoma. Liver resection was indicated and liver cirrhosis was observed with high portal pressure after transection. The treatment strategy was switched from right hepatectomy to ALPPS. The patient developed severe liver dysfunction and liver transplantation was indicated. His postoperative course was uneventful and 3 months after the procedure the patient was without complications. CONCLUSIONS Living donor liver transplantation may be necessary as a rescue procedure for patients who underwent ALPPS and develop liver dysfunction.</description><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Hepatectomy - methods</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis B, Chronic - diagnosis</subject><subject>Hepatitis B, Chronic - surgery</subject><subject>Humans</subject><subject>Ligation - methods</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver Failure - etiology</subject><subject>Liver Failure - physiopathology</subject><subject>Liver Failure - surgery</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation - methods</subject><subject>Living Donors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Portal Vein - surgery</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Salvage Therapy</subject><subject>Treatment Outcome</subject><issn>1941-5923</issn><issn>1941-5923</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV1P2zAYhaNp00CMu11PvmTSCv5InORmUtVtMFRpEYXt0nrn2KmnxC62A-qP47_NbQCBJcsf5_F7bJ8s-0jwKaG8qM_ml4ur05oQXudvskNS52RW1JS9fTE_yI5D-IdT45SXlL3PDhjOcV1zfJg9LM2dsR365qzzKC2UR9cebNj0YCOCgK5UkKNCq9F3ym-RThigBqJRSb83cY0u1Aaik6rvxx48WoCXxroB0J-1Qze2Vf5-x85DcNKkg8luMmrARxONswhsixrnI_TotzI26R3shZ3dKkKn2slGyeiGLTqZL5tm9flD9k5DH9Tx43iU3fz4fr24mC1_nf9czJczyao8zkiJC5XzGlOquZak1bzEJJeFrEjaYaxmqqUy17zCuuS0IBhSLwitSJlrzY6yr1Pdzfh3UK1Mz_HQi403A_itcGDEa8WatejcneCUVUVepAInjwW8ux1ViGIwYfdjYJUbg6CEUVpWfI9-mVDpXQhe6WcbgsU-dLELXUyhJ_zTy6s9w08Rs__gVKoN</recordid><startdate>20181109</startdate><enddate>20181109</enddate><creator>Fernandes, Eduardo de Souza Martins</creator><creator>de Mello, Felipe Pedreira Tavares</creator><creator>Andrade, Ronaldo Oliveira</creator><creator>Girao, Camila Liberato</creator><creator>Pimentel, Leandro Savattone</creator><creator>Cesar, Camilla</creator><creator>Sousa, Claudia Cristina</creator><creator>Brito-Azevedo, Anderson</creator><creator>Basto, Samanta Teixeira</creator><creator>Torres, Orlando Jorge Martins</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181109</creationdate><title>Living Donor Liver Transplant as Rescue Surgery for a Patient with Hepatocellular Carcinoma Who Underwent Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS)</title><author>Fernandes, Eduardo de Souza Martins ; de Mello, Felipe Pedreira Tavares ; Andrade, Ronaldo Oliveira ; Girao, Camila Liberato ; Pimentel, Leandro Savattone ; Cesar, Camilla ; Sousa, Claudia Cristina ; Brito-Azevedo, Anderson ; Basto, Samanta Teixeira ; Torres, Orlando Jorge Martins</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-1705e469022f6fc1df67014c5c812f63393ed2c4f680f762510a5105128174ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Hepatectomy - methods</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatitis B, Chronic - diagnosis</topic><topic>Hepatitis B, Chronic - surgery</topic><topic>Humans</topic><topic>Ligation - methods</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver Cirrhosis - surgery</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver Failure - etiology</topic><topic>Liver Failure - physiopathology</topic><topic>Liver Failure - surgery</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation - methods</topic><topic>Living Donors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Portal Vein - surgery</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Salvage Therapy</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Fernandes, Eduardo de Souza Martins</creatorcontrib><creatorcontrib>de Mello, Felipe Pedreira Tavares</creatorcontrib><creatorcontrib>Andrade, Ronaldo Oliveira</creatorcontrib><creatorcontrib>Girao, Camila Liberato</creatorcontrib><creatorcontrib>Pimentel, Leandro Savattone</creatorcontrib><creatorcontrib>Cesar, Camilla</creatorcontrib><creatorcontrib>Sousa, Claudia Cristina</creatorcontrib><creatorcontrib>Brito-Azevedo, Anderson</creatorcontrib><creatorcontrib>Basto, Samanta Teixeira</creatorcontrib><creatorcontrib>Torres, Orlando Jorge Martins</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandes, Eduardo de Souza Martins</au><au>de Mello, Felipe Pedreira Tavares</au><au>Andrade, Ronaldo Oliveira</au><au>Girao, Camila Liberato</au><au>Pimentel, Leandro Savattone</au><au>Cesar, Camilla</au><au>Sousa, Claudia Cristina</au><au>Brito-Azevedo, Anderson</au><au>Basto, Samanta Teixeira</au><au>Torres, Orlando Jorge Martins</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Living Donor Liver Transplant as Rescue Surgery for a Patient with Hepatocellular Carcinoma Who Underwent Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS)</atitle><jtitle>The American journal of case reports</jtitle><addtitle>Am J Case Rep</addtitle><date>2018-11-09</date><risdate>2018</risdate><volume>19</volume><spage>1338</spage><epage>1341</epage><pages>1338-1341</pages><issn>1941-5923</issn><eissn>1941-5923</eissn><abstract>BACKGROUND The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an important tool to induce fast liver hypertrophy. The degree of hepatic fibrosis/cirrhosis in patients with HCC negatively impacts their health, and the risk of liver failure is always present. In these cases, liver transplantation may be necessary as a rescue procedure. We present the case of a patient with HCC who underwent ALPPS and developed liver failure. A living donor liver transplant was performed as a rescue procedure. CASE REPORT A 49-year-old man with chronic hepatitis B without cirrhosis underwent computed tomography, which revealed an expansive lesion in the right lobe of his liver that was diagnosed as hepatocellular carcinoma. Liver resection was indicated and liver cirrhosis was observed with high portal pressure after transection. The treatment strategy was switched from right hepatectomy to ALPPS. The patient developed severe liver dysfunction and liver transplantation was indicated. His postoperative course was uneventful and 3 months after the procedure the patient was without complications. CONCLUSIONS Living donor liver transplantation may be necessary as a rescue procedure for patients who underwent ALPPS and develop liver dysfunction.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>30409960</pmid><doi>10.12659/AJCR.911694</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1941-5923 |
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| subjects | Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Hepatectomy - methods Hepatitis B, Chronic - complications Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - surgery Humans Ligation - methods Liver Cirrhosis - pathology Liver Cirrhosis - surgery Liver Cirrhosis - virology Liver Failure - etiology Liver Failure - physiopathology Liver Failure - surgery Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation - methods Living Donors Male Middle Aged Portal Vein - surgery Prognosis Risk Assessment Salvage Therapy Treatment Outcome |
| title | Living Donor Liver Transplant as Rescue Surgery for a Patient with Hepatocellular Carcinoma Who Underwent Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) |
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