BACE2 distribution in major brain cell types and identification of novel substrates

β-Site APP-cleaving enzyme 1 (BACE1) inhibition is considered one of the most promising therapeutic strategies for Alzheimer's disease, but current BACE1 inhibitors also block BACE2. As the localization and function of BACE2 in the brain remain unknown, it is difficult to predict whether releva...

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Veröffentlicht in:	Life science alliance 2018-01, Vol.1 (1), p.e201800026-e201800026
Hauptverfasser:	Voytyuk, Iryna, Mueller, Stephan A, Herber, Julia, Snellinx, An, Moechars, Dieder, van Loo, Geert, Lichtenthaler, Stefan F, De Strooper, Bart
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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