The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis
Objective: Type 2 diabetes is a risk factor for the development of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction. Our aim was to provide a summary estimate of the prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejectio...
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| Veröffentlicht in: | Diabetes & vascular disease research 2018-11, Vol.15 (6), p.477-493 |
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| creator | Bouthoorn, Selma Valstar, Gideon B Gohar, Aisha den Ruijter, Hester M Reitsma, Hans B Hoes, Arno W Rutten, Frans H |
| description | Objective:
Type 2 diabetes is a risk factor for the development of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction. Our aim was to provide a summary estimate of the prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in type 2 diabetes patients and to investigate sex disparities.
Methods and results:
A systematic search of the databases Medline and Embase was conducted for studies reporting the prevalence of left ventricular diastolic dysfunction or heart failure with preserved ejection fraction among type 2 diabetes patients. Studies were only included if echocardiography was performed. Prevalence estimates were pooled using random-effects meta-analysis. A total of 28 studies were included. Data on the prevalence of left ventricular diastolic dysfunction were available in 27 studies. The pooled prevalence for left ventricular diastolic dysfunction in the hospital population (2959 type 2 diabetes participants) and in the general population (2813 type 2 diabetes participants) was 48% [95% confidence interval: 38%–59%] and 35% (95% confidence interval: 24%–46%), respectively. Heterogeneity was high in both populations, with estimates ranging from 19% to 81% in the hospital population and from 23% to 54% in the general population. For women and men, the pooled prevalence estimates of left ventricular diastolic dysfunction were 47% (95% confidence interval: 37%–58%) and 46% (95% confidence interval: 37%–55%), respectively. Only two studies presented the prevalence of heart failure with preserved ejection fraction; 8% (95% confidence interval: 5%–14%) in a hospital population and 25% (95% confidence interval: 21%–28%) in the general population [18% in men (mean age: 73.8; standard deviation: 8.6) and 28% in women (mean age: 74.9; standard deviation: 6.9)].
Conclusion:
The prevalence of left ventricular diastolic dysfunction among type 2 diabetes patients is similarly high in men and women, while heart failure with preserved ejection fraction seems to be more common in women than men, at least in community people with type 2 diabetes. |
| doi_str_mv | 10.1177/1479164118787415 |
| format | Article |
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Type 2 diabetes is a risk factor for the development of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction. Our aim was to provide a summary estimate of the prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in type 2 diabetes patients and to investigate sex disparities.
Methods and results:
A systematic search of the databases Medline and Embase was conducted for studies reporting the prevalence of left ventricular diastolic dysfunction or heart failure with preserved ejection fraction among type 2 diabetes patients. Studies were only included if echocardiography was performed. Prevalence estimates were pooled using random-effects meta-analysis. A total of 28 studies were included. Data on the prevalence of left ventricular diastolic dysfunction were available in 27 studies. The pooled prevalence for left ventricular diastolic dysfunction in the hospital population (2959 type 2 diabetes participants) and in the general population (2813 type 2 diabetes participants) was 48% [95% confidence interval: 38%–59%] and 35% (95% confidence interval: 24%–46%), respectively. Heterogeneity was high in both populations, with estimates ranging from 19% to 81% in the hospital population and from 23% to 54% in the general population. For women and men, the pooled prevalence estimates of left ventricular diastolic dysfunction were 47% (95% confidence interval: 37%–58%) and 46% (95% confidence interval: 37%–55%), respectively. Only two studies presented the prevalence of heart failure with preserved ejection fraction; 8% (95% confidence interval: 5%–14%) in a hospital population and 25% (95% confidence interval: 21%–28%) in the general population [18% in men (mean age: 73.8; standard deviation: 8.6) and 28% in women (mean age: 74.9; standard deviation: 6.9)].
Conclusion:
The prevalence of left ventricular diastolic dysfunction among type 2 diabetes patients is similarly high in men and women, while heart failure with preserved ejection fraction seems to be more common in women than men, at least in community people with type 2 diabetes.</description><identifier>ISSN: 1479-1641</identifier><identifier>EISSN: 1752-8984</identifier><identifier>DOI: 10.1177/1479164118787415</identifier><identifier>PMID: 30037278</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetic Cardiomyopathies - diagnostic imaging ; Diabetic Cardiomyopathies - epidemiology ; Diabetic Cardiomyopathies - physiopathology ; Diastole ; Echocardiography ; Female ; Heart Failure - diagnostic imaging ; Heart Failure - epidemiology ; Heart Failure - physiopathology ; Humans ; Male ; Middle Aged ; Prevalence ; Prognosis ; Review ; Risk Factors ; Sex Distribution ; Stroke Volume ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - epidemiology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left</subject><ispartof>Diabetes & vascular disease research, 2018-11, Vol.15 (6), p.477-493</ispartof><rights>The Author(s) 2018</rights><rights>The Author(s) 2018 2018 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-3a21a139da123834f7e46dd1fa83ea3d60da60707c2b2e6eb69b9253add914df3</citedby><cites>FETCH-LOGICAL-c434t-3a21a139da123834f7e46dd1fa83ea3d60da60707c2b2e6eb69b9253add914df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1479164118787415$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1479164118787415$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,780,784,792,885,21966,27853,27922,27924,27925,44945,45333</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30037278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouthoorn, Selma</creatorcontrib><creatorcontrib>Valstar, Gideon B</creatorcontrib><creatorcontrib>Gohar, Aisha</creatorcontrib><creatorcontrib>den Ruijter, Hester M</creatorcontrib><creatorcontrib>Reitsma, Hans B</creatorcontrib><creatorcontrib>Hoes, Arno W</creatorcontrib><creatorcontrib>Rutten, Frans H</creatorcontrib><title>The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis</title><title>Diabetes & vascular disease research</title><addtitle>Diab Vasc Dis Res</addtitle><description>Objective:
Type 2 diabetes is a risk factor for the development of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction. Our aim was to provide a summary estimate of the prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in type 2 diabetes patients and to investigate sex disparities.
Methods and results:
A systematic search of the databases Medline and Embase was conducted for studies reporting the prevalence of left ventricular diastolic dysfunction or heart failure with preserved ejection fraction among type 2 diabetes patients. Studies were only included if echocardiography was performed. Prevalence estimates were pooled using random-effects meta-analysis. A total of 28 studies were included. Data on the prevalence of left ventricular diastolic dysfunction were available in 27 studies. The pooled prevalence for left ventricular diastolic dysfunction in the hospital population (2959 type 2 diabetes participants) and in the general population (2813 type 2 diabetes participants) was 48% [95% confidence interval: 38%–59%] and 35% (95% confidence interval: 24%–46%), respectively. Heterogeneity was high in both populations, with estimates ranging from 19% to 81% in the hospital population and from 23% to 54% in the general population. For women and men, the pooled prevalence estimates of left ventricular diastolic dysfunction were 47% (95% confidence interval: 37%–58%) and 46% (95% confidence interval: 37%–55%), respectively. Only two studies presented the prevalence of heart failure with preserved ejection fraction; 8% (95% confidence interval: 5%–14%) in a hospital population and 25% (95% confidence interval: 21%–28%) in the general population [18% in men (mean age: 73.8; standard deviation: 8.6) and 28% in women (mean age: 74.9; standard deviation: 6.9)].
Conclusion:
The prevalence of left ventricular diastolic dysfunction among type 2 diabetes patients is similarly high in men and women, while heart failure with preserved ejection fraction seems to be more common in women than men, at least in community people with type 2 diabetes.</description><subject>Adult</subject><subject>Aged</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetic Cardiomyopathies - diagnostic imaging</subject><subject>Diabetic Cardiomyopathies - epidemiology</subject><subject>Diabetic Cardiomyopathies - physiopathology</subject><subject>Diastole</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Stroke Volume</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - epidemiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left</subject><issn>1479-1641</issn><issn>1752-8984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp1Uctu1TAQjRCIlsKeFfKSTcCv2AkLpKriJVViU9bWJJ70-sqJL7Zzr_Jn_TySplSAxGqONOcxmlMUrxl9x5jW75nUDVOSsVrXWrLqSXHOdMXLuqnl0wUv63LdnxUvUtpTWild1c-LM0Gp0FzX58XdzQ7JIeIRPI4dktATj30mRxxzdN3kIRLrIOXgXUfsnPpp7LILI4HRkh1CzKQH56eI5OTybvVKGI9oCe5xY_YRNuBGMuCmPIUV3SvyfEDC15QWM6YP5JKkOWUcIC-Ry2kOT_eaATOUMIKfk0svi2c9-ISvHuZF8ePzp5urr-X19y_fri6vy04KmUsBnAETjQXGRS1kr1Eqa1kPtUAQVlELimqqO95yVNiqpm14JcDahknbi4vi4-Z7mNoBbbf-Bbw5RDdAnE0AZ_7ejG5nbsPRKC6UktVi8PbBIIafE6ZsBpc69B5GDFMynOqqkhXnfKHSjdrFkFLE_jGGUbMWbv4tfJG8-fO8R8HvhhdCuRES3KLZhykuD0z_N_wF_8S41g</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Bouthoorn, Selma</creator><creator>Valstar, Gideon B</creator><creator>Gohar, Aisha</creator><creator>den Ruijter, Hester M</creator><creator>Reitsma, Hans B</creator><creator>Hoes, Arno W</creator><creator>Rutten, Frans H</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis</title><author>Bouthoorn, Selma ; Valstar, Gideon B ; Gohar, Aisha ; den Ruijter, Hester M ; Reitsma, Hans B ; Hoes, Arno W ; Rutten, Frans H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-3a21a139da123834f7e46dd1fa83ea3d60da60707c2b2e6eb69b9253add914df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetic Cardiomyopathies - diagnostic imaging</topic><topic>Diabetic Cardiomyopathies - epidemiology</topic><topic>Diabetic Cardiomyopathies - physiopathology</topic><topic>Diastole</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Stroke Volume</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - epidemiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouthoorn, Selma</creatorcontrib><creatorcontrib>Valstar, Gideon B</creatorcontrib><creatorcontrib>Gohar, Aisha</creatorcontrib><creatorcontrib>den Ruijter, Hester M</creatorcontrib><creatorcontrib>Reitsma, Hans B</creatorcontrib><creatorcontrib>Hoes, Arno W</creatorcontrib><creatorcontrib>Rutten, Frans H</creatorcontrib><collection>SAGE Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes & vascular disease research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouthoorn, Selma</au><au>Valstar, Gideon B</au><au>Gohar, Aisha</au><au>den Ruijter, Hester M</au><au>Reitsma, Hans B</au><au>Hoes, Arno W</au><au>Rutten, Frans H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis</atitle><jtitle>Diabetes & vascular disease research</jtitle><addtitle>Diab Vasc Dis Res</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>15</volume><issue>6</issue><spage>477</spage><epage>493</epage><pages>477-493</pages><issn>1479-1641</issn><eissn>1752-8984</eissn><abstract>Objective:
Type 2 diabetes is a risk factor for the development of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction. Our aim was to provide a summary estimate of the prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in type 2 diabetes patients and to investigate sex disparities.
Methods and results:
A systematic search of the databases Medline and Embase was conducted for studies reporting the prevalence of left ventricular diastolic dysfunction or heart failure with preserved ejection fraction among type 2 diabetes patients. Studies were only included if echocardiography was performed. Prevalence estimates were pooled using random-effects meta-analysis. A total of 28 studies were included. Data on the prevalence of left ventricular diastolic dysfunction were available in 27 studies. The pooled prevalence for left ventricular diastolic dysfunction in the hospital population (2959 type 2 diabetes participants) and in the general population (2813 type 2 diabetes participants) was 48% [95% confidence interval: 38%–59%] and 35% (95% confidence interval: 24%–46%), respectively. Heterogeneity was high in both populations, with estimates ranging from 19% to 81% in the hospital population and from 23% to 54% in the general population. For women and men, the pooled prevalence estimates of left ventricular diastolic dysfunction were 47% (95% confidence interval: 37%–58%) and 46% (95% confidence interval: 37%–55%), respectively. Only two studies presented the prevalence of heart failure with preserved ejection fraction; 8% (95% confidence interval: 5%–14%) in a hospital population and 25% (95% confidence interval: 21%–28%) in the general population [18% in men (mean age: 73.8; standard deviation: 8.6) and 28% in women (mean age: 74.9; standard deviation: 6.9)].
Conclusion:
The prevalence of left ventricular diastolic dysfunction among type 2 diabetes patients is similarly high in men and women, while heart failure with preserved ejection fraction seems to be more common in women than men, at least in community people with type 2 diabetes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30037278</pmid><doi>10.1177/1479164118787415</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetic Cardiomyopathies - diagnostic imaging Diabetic Cardiomyopathies - epidemiology Diabetic Cardiomyopathies - physiopathology Diastole Echocardiography Female Heart Failure - diagnostic imaging Heart Failure - epidemiology Heart Failure - physiopathology Humans Male Middle Aged Prevalence Prognosis Review Risk Factors Sex Distribution Stroke Volume Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - epidemiology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left |
| title | The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis |
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