Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study
Background: Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events...
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| Veröffentlicht in: | Canadian journal of plastic surgery 2018-11, Vol.26 (4), p.250-255 |
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| creator | Wiser, Itay Roni, Averbuch Sagie Ziv, Ella Friedman, Mony Efraty, Shay Heller, Lior Landau, Marina Friedman, Tali |
| description | Background:
Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events.
Methods:
This is a pilot randomized controlled clinical study. Women following PCP underwent 5 consecutive daily HBOT sessions, compared with PCP alone. Pain, pruritus, erythema, crusting, scaling, and edema were daily evaluated up to 28 days following PCP. Photographs taken on days 14 and 35 following PCP were assessed. Confidence to appear in public was assessed 14 days following PCP.
Results:
Eight participants equally assigned to HBOT and control groups. Lower severity scores for erythema, scaling, and pruritus were documented in the HBOT group (mean difference 1.19, P = .006; .84, P = .04; and 2.19, P = .001, respectively). Photographic assessment severity score was higher for skin tightness, edema, erythema, crusting, and scaling in the control group on day 14 post PCP (P < .05) and for erythema on day 35 post PCP (P < .05). Epithelialization percentage was higher in the HBOT group on day 14 post PCP compared with controls (98.5% ± 1% vs 94.2% ± 1%; P = .021). The HBOT group scored higher in confidence to appear in public (20.8 ± 1.7 vs 14.5 ± 1.3; P = .029).
Conclusion:
Hyperbaric oxygen therapy following PCP is associated with faster recovery as assessed by both patients and caregivers. So far, HBOT was mainly used in the treatment of problematic or chronic wounds. Our study suggests expanding the indications in which hyperbaric oxygen treatment is applicable and recommended. |
| doi_str_mv | 10.1177/2292550317749511 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6236503</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2292550317749511</sage_id><sourcerecordid>2188185395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-58e251e8136169ff3a22382ca4cafe95a4cad684a3c3af3a971e11c6af07db9a3</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi1ERau2d07IEhcuKf5MnAtoWQpdqdJWUM6W15nsukriYCeF8BP41Xi77QKV4DSjeZ937LEHoeeUnFFaFK8ZK5mUhKdclJLSJ-hoW8pkyp_uc8IP0WmMN4QQKiTPhXqGDjkRSRD8CP1cRHy9gQDYdHgWo7fODM53-B0M3wA6fDH1EFYmOIuX36d1qmxx00_JUOFF2wd_CxVejoP1LWBf4_cAPZ5voHXWNPgKoHHd-i2e4U_J4Vv3I-FXrvEDniflDvo8jNV0gg5q00Q4vY_H6MuH8-v5RXa5_LiYzy4zK0oyZFIBkxQU5TnNy7rmhjGumDXCmhpKuY1VroThlpuklgUFSm1ualJUq9LwY_Rm17cfVy1UFrohmEb3wbUmTNobp_9WOrfRa3-rc8bz9Gypwav7BsF_HSEOunXRQtOYDvwYNaNc5oKWokjoy0fojR9Dl8bTTDBCpUqz_JeiSlEleSkTRXaUDT7GAPX-ypTo7UboxxuRLC_-HHVvePj_BGQ7IJo1_D71nw1_AX9Rvb4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2188185395</pqid></control><display><type>article</type><title>Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study</title><source>Access via SAGE</source><source>PubMed Central</source><creator>Wiser, Itay ; Roni, Averbuch Sagie ; Ziv, Ella ; Friedman, Mony ; Efraty, Shay ; Heller, Lior ; Landau, Marina ; Friedman, Tali</creator><creatorcontrib>Wiser, Itay ; Roni, Averbuch Sagie ; Ziv, Ella ; Friedman, Mony ; Efraty, Shay ; Heller, Lior ; Landau, Marina ; Friedman, Tali</creatorcontrib><description>Background:
Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events.
Methods:
This is a pilot randomized controlled clinical study. Women following PCP underwent 5 consecutive daily HBOT sessions, compared with PCP alone. Pain, pruritus, erythema, crusting, scaling, and edema were daily evaluated up to 28 days following PCP. Photographs taken on days 14 and 35 following PCP were assessed. Confidence to appear in public was assessed 14 days following PCP.
Results:
Eight participants equally assigned to HBOT and control groups. Lower severity scores for erythema, scaling, and pruritus were documented in the HBOT group (mean difference 1.19, P = .006; .84, P = .04; and 2.19, P = .001, respectively). Photographic assessment severity score was higher for skin tightness, edema, erythema, crusting, and scaling in the control group on day 14 post PCP (P < .05) and for erythema on day 35 post PCP (P < .05). Epithelialization percentage was higher in the HBOT group on day 14 post PCP compared with controls (98.5% ± 1% vs 94.2% ± 1%; P = .021). The HBOT group scored higher in confidence to appear in public (20.8 ± 1.7 vs 14.5 ± 1.3; P = .029).
Conclusion:
Hyperbaric oxygen therapy following PCP is associated with faster recovery as assessed by both patients and caregivers. So far, HBOT was mainly used in the treatment of problematic or chronic wounds. Our study suggests expanding the indications in which hyperbaric oxygen treatment is applicable and recommended.</description><identifier>ISSN: 2292-5503</identifier><identifier>EISSN: 2292-5511</identifier><identifier>DOI: 10.1177/2292550317749511</identifier><identifier>PMID: 30450343</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Chemical peels ; Dermatology ; Diabetes ; Edema ; Erythema ; Original ; Oxygen therapy ; Phenols ; Pruritus ; Respiratory therapy ; Tumor necrosis factor-TNF ; Ulcers ; Wound healing</subject><ispartof>Canadian journal of plastic surgery, 2018-11, Vol.26 (4), p.250-255</ispartof><rights>2018 The Author(s)</rights><rights>Copyright SAGE PUBLICATIONS, INC. Winter 2018</rights><rights>2018 The Author(s) 2018 Plastic Surgery Journal Corporation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-58e251e8136169ff3a22382ca4cafe95a4cad684a3c3af3a971e11c6af07db9a3</citedby><cites>FETCH-LOGICAL-c490t-58e251e8136169ff3a22382ca4cafe95a4cad684a3c3af3a971e11c6af07db9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236503/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236503/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21819,27924,27925,43621,43622,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30450343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiser, Itay</creatorcontrib><creatorcontrib>Roni, Averbuch Sagie</creatorcontrib><creatorcontrib>Ziv, Ella</creatorcontrib><creatorcontrib>Friedman, Mony</creatorcontrib><creatorcontrib>Efraty, Shay</creatorcontrib><creatorcontrib>Heller, Lior</creatorcontrib><creatorcontrib>Landau, Marina</creatorcontrib><creatorcontrib>Friedman, Tali</creatorcontrib><title>Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study</title><title>Canadian journal of plastic surgery</title><addtitle>Plast Surg (Oakv)</addtitle><description>Background:
Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events.
Methods:
This is a pilot randomized controlled clinical study. Women following PCP underwent 5 consecutive daily HBOT sessions, compared with PCP alone. Pain, pruritus, erythema, crusting, scaling, and edema were daily evaluated up to 28 days following PCP. Photographs taken on days 14 and 35 following PCP were assessed. Confidence to appear in public was assessed 14 days following PCP.
Results:
Eight participants equally assigned to HBOT and control groups. Lower severity scores for erythema, scaling, and pruritus were documented in the HBOT group (mean difference 1.19, P = .006; .84, P = .04; and 2.19, P = .001, respectively). Photographic assessment severity score was higher for skin tightness, edema, erythema, crusting, and scaling in the control group on day 14 post PCP (P < .05) and for erythema on day 35 post PCP (P < .05). Epithelialization percentage was higher in the HBOT group on day 14 post PCP compared with controls (98.5% ± 1% vs 94.2% ± 1%; P = .021). The HBOT group scored higher in confidence to appear in public (20.8 ± 1.7 vs 14.5 ± 1.3; P = .029).
Conclusion:
Hyperbaric oxygen therapy following PCP is associated with faster recovery as assessed by both patients and caregivers. So far, HBOT was mainly used in the treatment of problematic or chronic wounds. Our study suggests expanding the indications in which hyperbaric oxygen treatment is applicable and recommended.</description><subject>Chemical peels</subject><subject>Dermatology</subject><subject>Diabetes</subject><subject>Edema</subject><subject>Erythema</subject><subject>Original</subject><subject>Oxygen therapy</subject><subject>Phenols</subject><subject>Pruritus</subject><subject>Respiratory therapy</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ulcers</subject><subject>Wound healing</subject><issn>2292-5503</issn><issn>2292-5511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kk1v1DAQhi1ERau2d07IEhcuKf5MnAtoWQpdqdJWUM6W15nsukriYCeF8BP41Xi77QKV4DSjeZ937LEHoeeUnFFaFK8ZK5mUhKdclJLSJ-hoW8pkyp_uc8IP0WmMN4QQKiTPhXqGDjkRSRD8CP1cRHy9gQDYdHgWo7fODM53-B0M3wA6fDH1EFYmOIuX36d1qmxx00_JUOFF2wd_CxVejoP1LWBf4_cAPZ5voHXWNPgKoHHd-i2e4U_J4Vv3I-FXrvEDniflDvo8jNV0gg5q00Q4vY_H6MuH8-v5RXa5_LiYzy4zK0oyZFIBkxQU5TnNy7rmhjGumDXCmhpKuY1VroThlpuklgUFSm1ualJUq9LwY_Rm17cfVy1UFrohmEb3wbUmTNobp_9WOrfRa3-rc8bz9Gypwav7BsF_HSEOunXRQtOYDvwYNaNc5oKWokjoy0fojR9Dl8bTTDBCpUqz_JeiSlEleSkTRXaUDT7GAPX-ypTo7UboxxuRLC_-HHVvePj_BGQ7IJo1_D71nw1_AX9Rvb4</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Wiser, Itay</creator><creator>Roni, Averbuch Sagie</creator><creator>Ziv, Ella</creator><creator>Friedman, Mony</creator><creator>Efraty, Shay</creator><creator>Heller, Lior</creator><creator>Landau, Marina</creator><creator>Friedman, Tali</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M3G</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study</title><author>Wiser, Itay ; Roni, Averbuch Sagie ; Ziv, Ella ; Friedman, Mony ; Efraty, Shay ; Heller, Lior ; Landau, Marina ; Friedman, Tali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-58e251e8136169ff3a22382ca4cafe95a4cad684a3c3af3a971e11c6af07db9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Chemical peels</topic><topic>Dermatology</topic><topic>Diabetes</topic><topic>Edema</topic><topic>Erythema</topic><topic>Original</topic><topic>Oxygen therapy</topic><topic>Phenols</topic><topic>Pruritus</topic><topic>Respiratory therapy</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ulcers</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiser, Itay</creatorcontrib><creatorcontrib>Roni, Averbuch Sagie</creatorcontrib><creatorcontrib>Ziv, Ella</creatorcontrib><creatorcontrib>Friedman, Mony</creatorcontrib><creatorcontrib>Efraty, Shay</creatorcontrib><creatorcontrib>Heller, Lior</creatorcontrib><creatorcontrib>Landau, Marina</creatorcontrib><creatorcontrib>Friedman, Tali</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>CBCA Reference & Current Events</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian journal of plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiser, Itay</au><au>Roni, Averbuch Sagie</au><au>Ziv, Ella</au><au>Friedman, Mony</au><au>Efraty, Shay</au><au>Heller, Lior</au><au>Landau, Marina</au><au>Friedman, Tali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study</atitle><jtitle>Canadian journal of plastic surgery</jtitle><addtitle>Plast Surg (Oakv)</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>26</volume><issue>4</issue><spage>250</spage><epage>255</epage><pages>250-255</pages><issn>2292-5503</issn><eissn>2292-5511</eissn><abstract>Background:
Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events.
Methods:
This is a pilot randomized controlled clinical study. Women following PCP underwent 5 consecutive daily HBOT sessions, compared with PCP alone. Pain, pruritus, erythema, crusting, scaling, and edema were daily evaluated up to 28 days following PCP. Photographs taken on days 14 and 35 following PCP were assessed. Confidence to appear in public was assessed 14 days following PCP.
Results:
Eight participants equally assigned to HBOT and control groups. Lower severity scores for erythema, scaling, and pruritus were documented in the HBOT group (mean difference 1.19, P = .006; .84, P = .04; and 2.19, P = .001, respectively). Photographic assessment severity score was higher for skin tightness, edema, erythema, crusting, and scaling in the control group on day 14 post PCP (P < .05) and for erythema on day 35 post PCP (P < .05). Epithelialization percentage was higher in the HBOT group on day 14 post PCP compared with controls (98.5% ± 1% vs 94.2% ± 1%; P = .021). The HBOT group scored higher in confidence to appear in public (20.8 ± 1.7 vs 14.5 ± 1.3; P = .029).
Conclusion:
Hyperbaric oxygen therapy following PCP is associated with faster recovery as assessed by both patients and caregivers. So far, HBOT was mainly used in the treatment of problematic or chronic wounds. Our study suggests expanding the indications in which hyperbaric oxygen treatment is applicable and recommended.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>30450343</pmid><doi>10.1177/2292550317749511</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Access via SAGE; PubMed Central |
| subjects | Chemical peels Dermatology Diabetes Edema Erythema Original Oxygen therapy Phenols Pruritus Respiratory therapy Tumor necrosis factor-TNF Ulcers Wound healing |
| title | Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study |
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