Putting a strain on diversity
Human life expectancy is increasing on a global scale, but healthspan—the period of life free from age‐associated ill health—is not improving at a comparable rate. This disconnect means that a greater proportion of the general population will spend a longer period of their life suffering from one or...
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| Veröffentlicht in: | The EMBO journal 2018-11, Vol.37 (22), p.n/a |
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| container_title | The EMBO journal |
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| creator | Selman, Colin Swindell, William R |
| description | Human life expectancy is increasing on a global scale, but healthspan—the period of life free from age‐associated ill health—is not improving at a comparable rate. This disconnect means that a greater proportion of the general population will spend a longer period of their life suffering from one or more debilitating age‐associated diseases, such as cardiovascular disease, Alzheimer's disease, osteoporosis, sarcopenia and various cancers. Understanding the processes underlying ageing and age‐related diseases is therefore a major and pressing research challenge in biomedical research.
Graphical Abstract
Quantitative proteomics identifies an ES cell‐specific form of a chromatin repressor complex, which shapes the particular chromatin state required for proliferation and self‐renewal of these cells. |
| doi_str_mv | 10.15252/embj.2018100862 |
| format | Article |
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Graphical Abstract
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Graphical Abstract
Quantitative proteomics identifies an ES cell‐specific form of a chromatin repressor complex, which shapes the particular chromatin state required for proliferation and self‐renewal of these cells.</description><subject>Age</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Cardiovascular diseases</subject><subject>Commentary</subject><subject>EMBO01</subject><subject>EMBO16</subject><subject>Life expectancy</subject><subject>Life span</subject><subject>Neurodegenerative diseases</subject><subject>Osteoporosis</subject><subject>Sarcopenia</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkM1LxDAUxIMouq7evSgLXrxUX5Im24AIKn6i6EHPIWlf1yzdVpN2Zf97o-s3iKd3eL8ZZoaQDQq7VDDB9nBix7sMaEYBMskWSI-mEhIGQ7FIesAkTVKaqRWyGsIYAEQ2pMtkhQPPlJS8RzZvu7Z19WhgBqH1xtWDph4Uboo-uHa2RpZKUwVcf799cn96cnd8nlzdnF0cH14luaCKJQZNAWiLzA7BlqCUNGkJhUGgAgVP0WKqUHHLc5FalRZDI1OTFyUzIK1hvE8O5r6PnZ1gkWMds1T60buJ8TPdGKd_fmr3oEfNVEvGJY9t-mTn3cA3Tx2GVk9cyLGqTI1NFzSjTAnOlOIR3f6FjpvO17FepDjnjFGqIgVzKvdNCB7LzzAU9Nv2-nV7_bV9lGx9L_Ep-Bg7Avtz4NlVOPvXUJ9cH13-8KdzeYjKeoT-K_ifmV4AabKg6A</recordid><startdate>20181115</startdate><enddate>20181115</enddate><creator>Selman, Colin</creator><creator>Swindell, William R</creator><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8504-6363</orcidid><orcidid>https://orcid.org/0000-0002-8727-0593</orcidid></search><sort><creationdate>20181115</creationdate><title>Putting a strain on diversity</title><author>Selman, Colin ; Swindell, William R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5192-aead0ebd8b70bf0996a4f0dae015e534ebe49e93b3c54b94d7a64acdf2a06ba23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Cardiovascular diseases</topic><topic>Commentary</topic><topic>EMBO01</topic><topic>EMBO16</topic><topic>Life expectancy</topic><topic>Life span</topic><topic>Neurodegenerative diseases</topic><topic>Osteoporosis</topic><topic>Sarcopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selman, Colin</creatorcontrib><creatorcontrib>Swindell, William R</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Selman, Colin</au><au>Swindell, William R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Putting a strain on diversity</atitle><jtitle>The EMBO journal</jtitle><stitle>EMBO J</stitle><addtitle>EMBO J</addtitle><date>2018-11-15</date><risdate>2018</risdate><volume>37</volume><issue>22</issue><epage>n/a</epage><issn>0261-4189</issn><eissn>1460-2075</eissn><abstract>Human life expectancy is increasing on a global scale, but healthspan—the period of life free from age‐associated ill health—is not improving at a comparable rate. 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Graphical Abstract
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| identifier | ISSN: 0261-4189 |
| ispartof | The EMBO journal, 2018-11, Vol.37 (22), p.n/a |
| issn | 0261-4189 1460-2075 |
| language | eng |
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| source | Springer Nature OA Free Journals |
| subjects | Age Aging Alzheimer's disease Biocompatibility Biomedical materials Cardiovascular diseases Commentary EMBO01 EMBO16 Life expectancy Life span Neurodegenerative diseases Osteoporosis Sarcopenia |
| title | Putting a strain on diversity |
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