miR‑371b‑5p inhibits endothelial cell apoptosis in monocrotaline‑induced pulmonary arterial hypertension via PTEN/PI3K/Akt signaling pathways

Pulmonary arterial hypertension (PAH) is a clinical hemodynamic syndrome. It is characterized by elevated PA pressure and pulmonary vascular resistance. In the present study, the role of microRNA (miRNA/miR)‑371b‑5p in monocrotaline‑induced PAH and the underlying mechanisms were investigated. In a m...

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Veröffentlicht in:	Molecular medicine reports 2018-12, Vol.18 (6), p.5489-5501
Hauptverfasser:	Zhu, Guangfa, Zhang, Wenmei, Liu, Yan, Wang, Shenghao
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Animals Apoptosis Apoptosis - genetics Cell growth Cell Proliferation Disease Models, Animal Endothelial cells Endothelial Cells - metabolism Gene Expression Profiling Genes, Reporter Genetic transcription Health aspects Humans Hypertension Hypertension, Pulmonary - etiology Hypertension, Pulmonary - metabolism Kinases Male MicroRNA MicroRNAs - genetics miRNA Models, Biological Monocrotaline Monocrotaline - adverse effects Mortality Nitric Oxide Synthase Type III - metabolism Phosphatidylinositol 3-Kinases - metabolism Polymerase chain reaction Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism PTEN protein Pulmonary hypertension Rats Reverse transcription Rodents Signal Transduction Tensin Transcription Factor AP-1 - metabolism
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