Lentiviral‑mediated inducible silencing of TLR4 attenuates neuropathic pain in a rat model of chronic constriction injury

An increasing body of evidence has indicated that spinal microglial Toll‑like receptor 4 (TLR4) may serve a significant role in the development and maintenance of neuropathic pain (NP). In the present study, experiments were conducted to evaluate the contribution of a tetracycline inducible lentivir...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular medicine reports 2018-12, Vol.18 (6), p.5545-5551
Hauptverfasser:	Liu, Yantao, Zhang, Yan, Pan, Ruirui, Chen, Mo, Wang, Xiaoqiang, Kong, Erliang, Yu, Weifeng, Sun, Yuming, Wu, Feixiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antibiotics Biochemical analysis Disease Models, Animal Doxycycline Enzyme-linked immunosorbent assay Gene expression Gene Silencing Gene therapy Genetic Vectors - genetics Health aspects Hyperalgesia Interleukin-1beta - metabolism Laboratory animals Latency Lentivirus Lentivirus - genetics Male Neuralgia - etiology Neuralgia - metabolism Neuropathy Pain Pain perception Physiological aspects Polymerase chain reaction Proteins Rats Rattus Reverse transcription RNA, Small Interfering - genetics Rodents Sciatic nerve Signal transduction siRNA Spinal cord Studies Surgery TLR4 TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Transduction, Genetic Tumor Necrosis Factor-alpha - metabolism Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!