Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

Immune cell infiltrates have proven highly relevant for colorectal carcinoma prognosis, making colorectal cancer a promising candidate for immunotherapy. Because tumors interact with the immune system via HLA-presented peptide ligands, exact knowledge of the peptidome constitution is fundamental for...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-08, Vol.78 (16), p.4627-4641
Hauptverfasser:	Löffler, Markus W, Kowalewski, Daniel J, Backert, Linus, Bernhardt, Jörg, Adam, Patrick, Schuster, Heiko, Dengler, Florian, Backes, Daniel, Kopp, Hans-Georg, Beckert, Stefan, Wagner, Silvia, Königsrainer, Ingmar, Kohlbacher, Oliver, Kanz, Lothar, Königsrainer, Alfred, Rammensee, Hans-Georg, Stevanović, Stefan, Haen, Sebastian P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics Antigen Presentation - immunology Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - immunology Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology HLA Antigens - genetics Humans Immunotherapy Ligands Mass Spectrometry Peptides - genetics Peptides - immunology T-Lymphocytes - immunology T-Lymphocytes - pathology
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