Nitric oxide triggers the assembly of “type II” stress granules linked to decreased cell viability

We show that 3-morpholinosydnonimine (SIN-1)-induced nitric oxide (NO) triggers the formation of SGs. Whereas the composition of NO-induced SGs is initially similar to sodium arsenite (SA)-induced type I (cytoprotective) SGs, the progressive loss of eIF3 over time converts them into pro-death (type...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death & disease 2018-11, Vol.9 (11), p.1129-14, Article 1129
Hauptverfasser:	Aulas, Anaïs, Lyons, Shawn M., Fay, Marta M., Anderson, Paul, Ivanov, Pavel
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14/1 14/19 14/33 38/32 42/35 631/337/1645 631/80/82 96/106 96/63 Adenosine Triphosphate - biosynthesis Animals Antibodies Apoptosis - drug effects Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Arsenite Arsenites - pharmacology Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line, Tumor Cell Survival - drug effects Cytoplasmic Granules - drug effects Cytoplasmic Granules - metabolism Cytoplasmic Granules - ultrastructure Energy balance Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Eukaryotic Initiation Factor-3 - genetics Eukaryotic Initiation Factor-3 - metabolism Eukaryotic Initiation Factor-4F - genetics Eukaryotic Initiation Factor-4F - metabolism Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation Guanine Humans Immunology Life Sciences Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Molsidomine - analogs & derivatives Molsidomine - metabolism Molsidomine - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - metabolism Nitric Oxide Donors - pharmacology Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Phosphorylation Protein Biosynthesis Reactive oxygen species Reactive Oxygen Species - metabolism Sodium arsenite Sodium Compounds - pharmacology Stress, Physiological TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!