Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist

Receptor-type protein tyrosine phosphatase D (PTPRD) is a neuronal cell-adhesion molecule/synaptic specifier that has been implicated in addiction vulnerability and stimulant reward by human genomewide association and mouse cocaine-conditioned place-preference data. However, there have been no repor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-11, Vol.115 (45), p.11597-11602
Hauptverfasser:	Uhl, George R., Martinez, Maria J., Paik, Paul, Sulima, Agnieszka, Bi, Guo-Hua, Iyer, Malliga R., Gardner, Eliot, Rice, Kenner C., Xi, Zheng-Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Animals Antagonist drugs Biological Sciences Catheters, Indwelling Cell adhesion & migration Cocaine Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - enzymology Cocaine-Related Disorders - genetics Cocaine-Related Disorders - physiopathology Conditioning Conditioning (Psychology) Coumarins - chemical synthesis Coumarins - pharmacology Disease Models, Animal Drug abuse Drug addiction Drug self-administration Gene Expression Regulation Humans Injections, Intravenous Lead compounds Ligands Mice Mice, Inbred C57BL Mice, Knockout Narcotic Antagonists - chemical synthesis Narcotic Antagonists - pharmacology Narcotics Neurons - drug effects Neurons - enzymology Neurons - pathology Place preference conditioning Protein-tyrosine-phosphatase Proteins Receptor-Like Protein Tyrosine Phosphatases, Class 2 - antagonists & inhibitors Receptor-Like Protein Tyrosine Phosphatases, Class 2 - deficiency Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics Reinforcement Reward Self Administration Signal Transduction Substance Abuse, Intravenous - drug therapy Substance Abuse, Intravenous - enzymology Substance Abuse, Intravenous - genetics Substance Abuse, Intravenous - physiopathology Toxicity Toxicity Tests, Acute Toxicity Tests, Chronic Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!