MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability

MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression in many diseases, although the contribution of miRNAs to the pathophysiology of lung injury remains obscure. We hypothesized that dysregulation of miRNA expression drives the changes in key genes implicated in the development of lun...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2018-10, Vol.315 (4), p.L584-L594
Hauptverfasser:	Good, Ryan J, Hernandez-Lagunas, Laura, Allawzi, Ayed, Maltzahn, Joanne K, Vohwinkel, Christine U, Upadhyay, Arun K, Kompella, Uday B, Birukov, Konstantin G, Carpenter, Todd C, Sucharov, Carmen C, Nozik-Grayck, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Bleomycin Bleomycin - toxicity Cadherins Cell adhesion Cell Membrane Permeability Cells, Cultured Endothelial cells Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology EphA2 protein Flow cytometry Gene expression Gene Expression Regulation Humans Injuries Lung diseases Lung Injury - chemically induced Lung Injury - genetics Lung Injury - metabolism Lung Injury - pathology Lungs Male Mice Mice, Inbred C57BL MicroRNAs MicroRNAs - genetics Microvasculature miRNA Pathophysiology Permeability Proteins Receptor, EphA2 - genetics Receptor, EphA2 - metabolism Ribonucleic acid RNA Target recognition Therapeutic applications Trachea
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