ErbB4 deletion predisposes to development of metabolic syndrome in mice

ErbB4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between ErbB4 and type 2 diabetes and obesity, but its role in metabolic syndrome (MetS) has not been reported. In the current study we found that mice...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2018-10, Vol.315 (4), p.E583-E593
Hauptverfasser:	Zeng, Fenghua, Wang, Yinqiu, Kloepfer, Lance A, Wang, Suwan, Harris, Raymond C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipogenesis Adiponectin Adipose tissue Animal tissues Browning Cell membranes Clonal deletion Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dyslipidemia ErbB-2 protein Fatty liver Genes Glucose Homeostasis Hyperglycemia Hyperinsulinemia Insulin Leptin Lipogenesis Lipolysis Macrophages Metabolic syndrome Mice Obesity Rodents Steatosis
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