Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log 10 CFU after two weeks of tr...

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Veröffentlicht in:	Scientific reports 2018-11, Vol.8 (1), p.16610-14, Article 16610
Hauptverfasser:	Upadhyay, Rashmi, Sanchez-Hidalgo, Andrea, Wilusz, Carol J., Lenaerts, Anne J., Arab, Jennifer, Yeh, Joanna, Stefanisko, Karen, Tarasova, Nadya I., Gonzalez-Juarrero, Mercedes
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/152 64/60 692/699/255/1856 82/51 96/1 96/2 96/21 96/31 96/63 Administration, Inhalation Aerosols Animals Antibiotics Apoptosis Arginase Autophagy Bacilli Chronic infection Drug Delivery Systems Enzymatic activity Female Humanities and Social Sciences Interleukin 1 Interleukin 10 Interleukin-10 - antagonists & inhibitors Lungs Lysozyme Mice Mice, Inbred C57BL multidisciplinary Mycobacterium tuberculosis - drug effects NAD(P)H oxidase Nitric oxide Nitric-oxide synthase Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Peptide inhibitors Peptides Phagocytosis Science Science (multidisciplinary) Stat3 protein STAT3 Transcription Factor - antagonists & inhibitors Tuberculosis Tuberculosis - drug therapy Tuberculosis - microbiology Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology
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