Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis

Context: Selenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine and a common edible food, hawthorn fruit extract (HE) was chosen as a reductant to prepare SeNPs. Objective:...

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Veröffentlicht in:	Pharmaceutical biology 2018-01, Vol.56 (1), p.528-534
Hauptverfasser:	Cui, Dongxiao, Liang, Tingting, Sun, Liqian, Meng, Liqiang, Yang, Congcong, Wang, Liwei, Liang, Taigang, Li, Qingshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V antineoplastic activity antitumor Antitumor activity Apoptosis Apoptosis - drug effects Bcl-2 protein Caspase 9 - metabolism Caspase-9 Cell Line Cell Survival - drug effects Chinese medicine Crataegus Crataegus - chemistry Cytotoxicity drug therapy Flow cytometry Fruit - chemistry fruit extracts fruits Green Chemistry Technology Hep G2 Cells human cell lines human diseases human liver cancer Humans inhibitory concentration 50 Intracellular Liver - cytology Liver - drug effects Liver - metabolism Liver cancer liver neoplasms Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical research Membrane potential Membrane Potential, Mitochondrial - drug effects Microorganisms Mitochondria Mitochondria - drug effects Mitochondria - metabolism mitochondrial membrane mitochondrial pathway Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanotechnology Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Pharmaceutical sciences Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology protein synthesis Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism reducing agents Selenium Selenium - chemistry Selenium - pharmacology stabilizers staining Trace element Trace elements traditional medicine Western blotting
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