Kinase domain activation through gene rearrangement in multiple myeloma

Chromosomal rearrangements that result in oncogenic kinase activation are present in many solid and hematological malignancies, but none have been reported in multiple myeloma (MM). Here we analyzed 1421 samples from 958 myeloma patients using a targeted assay and detected fusion genes in 1.5% of pa...

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Veröffentlicht in:	Leukemia 2018-11, Vol.32 (11), p.2435-2444
Hauptverfasser:	Morgan, Gareth J, He, Jie, Tytarenko, Ruslana, Patel, Purvi, Stephens, Owen W, Zhong, Shan, Deshpande, Shayu, Bauer, Michael, Weinhold, Niels, Schinke, Carolina, Rasche, Leo, Bailey, Mark, Ali, Siraj, Ross, Jeff, Miller, Vincent A, Stephens, Phillip, Thanendrarajan, Sharmilan, Zangari, Maurizio, van Rhee, Frits, Mughal, Tariq, Davies, Faith E, Walker, Brian A
Format:	Artikel
Sprache:	eng
Schlagworte:	38/61 45/23 45/70 45/91 631/208/69 692/308/2056 Amino Acid Sequence Anaplastic Lymphoma Kinase - genetics Cancer genetics Cancer patients Cancer Research Chromosome rearrangements Critical Care Medicine Diagnosis Domains Drug therapy Extracellular signal-regulated kinase Fibroblast growth factor receptor 1 Gene mutation Gene rearrangement Gene Rearrangement - genetics Genes Genetic aspects Genetic research Health aspects Hematology Humans Inflammation Intensive Internal Medicine Kinase inhibitors Kinases Medicine Medicine & Public Health Metabolic pathways Multiple myeloma Multiple Myeloma - genetics Mutation Mutation - genetics Neoplasm Recurrence, Local - genetics NF-kappa B - genetics NF-κB protein Oncogene Proteins, Fusion - genetics Oncology Pathogenesis Patients Phenols (Class of compounds) Phosphotransferases - genetics Protein Domains - genetics Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins B-raf - genetics Raf protein Receptor Protein-Tyrosine Kinases - genetics Signal Transduction - genetics Smoldering Transcription activation Tyrosine
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