A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women
Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate tr...
Gespeichert in:
| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2018-10, Vol.10 (10), p.2624-2635 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2635 |
|---|---|
| container_issue | 10 |
| container_start_page | 2624 |
| container_title | Aging (Albany, NY.) |
| container_volume | 10 |
| creator | Zhao, Qi Shen, Hui Su, Kuan-Jui Tian, Qing Zhao, Lan-Juan Qiu, Chuan Garrett, Timothy J Liu, Jiawang Kakhniashvili, David Deng, Hong-Wen |
| description | Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation. |
| doi_str_mv | 10.18632/aging.101574 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6224264</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2120201642</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-606755b6919ec1f52e19a62134d29819921983eb7383f9ae192a53f6668363663</originalsourceid><addsrcrecordid>eNpVkctLxDAQxoMoPlaPXiVHL9W8N7kIsvgCwYuewzRNu1naZG1axf_esruKnmaY7zffDHwInVNyRbXi7BqaEJsrSqiciz10TI2QhZDa7P_pj9BJzitClJRCHaIjTjjVQstjVN3iVQpxwBCh_coh41Tjzg9QpjZ1weF1n-rQ-owh5-QCDL7Cn2FY4m7MrvW4m-bTcoXz0PvYTEKIeAGjgxwg4s_U-XiKDmposz_b1Rl6u797XTwWzy8PT4vb58JxPR8KRdRcylIZaryjtWSeGlCMclExo6kxjBrNfTnnmtcGJpWB5LVSSnPFleIzdLP1XY9l5yvn49BDa9d96KD_sgmC_a_EsLRN-rCKMcGUmAwudwZ9eh99HmwXsvNtC9GnMVtGGWGEKsEmtNiirk85977-PUOJ3SRjN8nYbTITf_H3t1_6Jwr-DUKgiyY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2120201642</pqid></control><display><type>article</type><title>A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Zhao, Qi ; Shen, Hui ; Su, Kuan-Jui ; Tian, Qing ; Zhao, Lan-Juan ; Qiu, Chuan ; Garrett, Timothy J ; Liu, Jiawang ; Kakhniashvili, David ; Deng, Hong-Wen</creator><creatorcontrib>Zhao, Qi ; Shen, Hui ; Su, Kuan-Jui ; Tian, Qing ; Zhao, Lan-Juan ; Qiu, Chuan ; Garrett, Timothy J ; Liu, Jiawang ; Kakhniashvili, David ; Deng, Hong-Wen</creatorcontrib><description>Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.101574</identifier><identifier>PMID: 30318485</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Adult ; Biomarkers - blood ; Body Composition ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Energy Metabolism ; European Continental Ancestry Group ; Female ; Humans ; Metabolomics - methods ; Muscle Strength ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiopathology ; Pilot Projects ; Research Paper ; Sarcopenia - blood ; Sarcopenia - diagnosis ; Sarcopenia - physiopathology ; Sex Factors ; Spectrometry, Mass, Electrospray Ionization</subject><ispartof>Aging (Albany, NY.), 2018-10, Vol.10 (10), p.2624-2635</ispartof><rights>Copyright © 2018 Zhao et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-606755b6919ec1f52e19a62134d29819921983eb7383f9ae192a53f6668363663</citedby><cites>FETCH-LOGICAL-c387t-606755b6919ec1f52e19a62134d29819921983eb7383f9ae192a53f6668363663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224264/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224264/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30318485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Qi</creatorcontrib><creatorcontrib>Shen, Hui</creatorcontrib><creatorcontrib>Su, Kuan-Jui</creatorcontrib><creatorcontrib>Tian, Qing</creatorcontrib><creatorcontrib>Zhao, Lan-Juan</creatorcontrib><creatorcontrib>Qiu, Chuan</creatorcontrib><creatorcontrib>Garrett, Timothy J</creatorcontrib><creatorcontrib>Liu, Jiawang</creatorcontrib><creatorcontrib>Kakhniashvili, David</creatorcontrib><creatorcontrib>Deng, Hong-Wen</creatorcontrib><title>A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Body Composition</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Energy Metabolism</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Humans</subject><subject>Metabolomics - methods</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Pilot Projects</subject><subject>Research Paper</subject><subject>Sarcopenia - blood</subject><subject>Sarcopenia - diagnosis</subject><subject>Sarcopenia - physiopathology</subject><subject>Sex Factors</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctLxDAQxoMoPlaPXiVHL9W8N7kIsvgCwYuewzRNu1naZG1axf_esruKnmaY7zffDHwInVNyRbXi7BqaEJsrSqiciz10TI2QhZDa7P_pj9BJzitClJRCHaIjTjjVQstjVN3iVQpxwBCh_coh41Tjzg9QpjZ1weF1n-rQ-owh5-QCDL7Cn2FY4m7MrvW4m-bTcoXz0PvYTEKIeAGjgxwg4s_U-XiKDmposz_b1Rl6u797XTwWzy8PT4vb58JxPR8KRdRcylIZaryjtWSeGlCMclExo6kxjBrNfTnnmtcGJpWB5LVSSnPFleIzdLP1XY9l5yvn49BDa9d96KD_sgmC_a_EsLRN-rCKMcGUmAwudwZ9eh99HmwXsvNtC9GnMVtGGWGEKsEmtNiirk85977-PUOJ3SRjN8nYbTITf_H3t1_6Jwr-DUKgiyY</recordid><startdate>20181014</startdate><enddate>20181014</enddate><creator>Zhao, Qi</creator><creator>Shen, Hui</creator><creator>Su, Kuan-Jui</creator><creator>Tian, Qing</creator><creator>Zhao, Lan-Juan</creator><creator>Qiu, Chuan</creator><creator>Garrett, Timothy J</creator><creator>Liu, Jiawang</creator><creator>Kakhniashvili, David</creator><creator>Deng, Hong-Wen</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181014</creationdate><title>A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women</title><author>Zhao, Qi ; Shen, Hui ; Su, Kuan-Jui ; Tian, Qing ; Zhao, Lan-Juan ; Qiu, Chuan ; Garrett, Timothy J ; Liu, Jiawang ; Kakhniashvili, David ; Deng, Hong-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-606755b6919ec1f52e19a62134d29819921983eb7383f9ae192a53f6668363663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Body Composition</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cross-Sectional Studies</topic><topic>Energy Metabolism</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Humans</topic><topic>Metabolomics - methods</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Pilot Projects</topic><topic>Research Paper</topic><topic>Sarcopenia - blood</topic><topic>Sarcopenia - diagnosis</topic><topic>Sarcopenia - physiopathology</topic><topic>Sex Factors</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Qi</creatorcontrib><creatorcontrib>Shen, Hui</creatorcontrib><creatorcontrib>Su, Kuan-Jui</creatorcontrib><creatorcontrib>Tian, Qing</creatorcontrib><creatorcontrib>Zhao, Lan-Juan</creatorcontrib><creatorcontrib>Qiu, Chuan</creatorcontrib><creatorcontrib>Garrett, Timothy J</creatorcontrib><creatorcontrib>Liu, Jiawang</creatorcontrib><creatorcontrib>Kakhniashvili, David</creatorcontrib><creatorcontrib>Deng, Hong-Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Qi</au><au>Shen, Hui</au><au>Su, Kuan-Jui</au><au>Tian, Qing</au><au>Zhao, Lan-Juan</au><au>Qiu, Chuan</au><au>Garrett, Timothy J</au><au>Liu, Jiawang</au><au>Kakhniashvili, David</au><au>Deng, Hong-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2018-10-14</date><risdate>2018</risdate><volume>10</volume><issue>10</issue><spage>2624</spage><epage>2635</epage><pages>2624-2635</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.</abstract><cop>United States</cop><pub>Impact Journals</pub><pmid>30318485</pmid><doi>10.18632/aging.101574</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1945-4589 |
| ispartof | Aging (Albany, NY.), 2018-10, Vol.10 (10), p.2624-2635 |
| issn | 1945-4589 1945-4589 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6224264 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Biomarkers - blood Body Composition Chromatography, High Pressure Liquid Cross-Sectional Studies Energy Metabolism European Continental Ancestry Group Female Humans Metabolomics - methods Muscle Strength Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Pilot Projects Research Paper Sarcopenia - blood Sarcopenia - diagnosis Sarcopenia - physiopathology Sex Factors Spectrometry, Mass, Electrospray Ionization |
| title | A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T13%3A19%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20joint%20analysis%20of%20metabolomic%20profiles%20associated%20with%20muscle%20mass%20and%20strength%20in%20Caucasian%20women&rft.jtitle=Aging%20(Albany,%20NY.)&rft.au=Zhao,%20Qi&rft.date=2018-10-14&rft.volume=10&rft.issue=10&rft.spage=2624&rft.epage=2635&rft.pages=2624-2635&rft.issn=1945-4589&rft.eissn=1945-4589&rft_id=info:doi/10.18632/aging.101574&rft_dat=%3Cproquest_pubme%3E2120201642%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2120201642&rft_id=info:pmid/30318485&rfr_iscdi=true |