Lessons learned from the PRESERVE trial
The recently published Prevention of Serious Adverse Events Following Angiography (PRESERVE) trial is presently the largest and most comprehensive clinical trial comparing commonly applied strategies for prevention of iodinated contrast-induced acute kidney injury in high-risk patients. The fundamen...
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| Veröffentlicht in: | British journal of radiology 2018-07, Vol.91 (1087), p.20180092-20180092 |
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| container_issue | 1087 |
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| container_title | British journal of radiology |
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| creator | Partovi, Sasan Trischman, Thomas Kang, Preet S |
| description | The recently published Prevention of Serious Adverse Events Following Angiography (PRESERVE) trial is presently the largest and most comprehensive clinical trial comparing commonly applied strategies for prevention of iodinated contrast-induced acute kidney injury in high-risk patients. The fundamental conclusion of the PRESERVE trial is that oral acetylcysteine and i.v. sodium bicarbonate are not superior to simple i.v. hydration with isotonic saline for the prevention of contrast-induced renal sequelae. In this commentary, we discuss the results in the context of selected past major trials, and provide insights into the strengths and potential weaknesses of the PRESERVE trial. In the future, developing individualized preventive approaches to avoid contrast-induced acute kidney injury for different patient populations is recommended. |
| doi_str_mv | 10.1259/bjr.20180092 |
| format | Article |
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| ispartof | British journal of radiology, 2018-07, Vol.91 (1087), p.20180092-20180092 |
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| subjects | Acetylcysteine - therapeutic use Acute Kidney Injury - chemically induced Acute Kidney Injury - prevention & control Administration, Intravenous Administration, Oral Angiography Contrast Media - adverse effects Female Free Radical Scavengers - therapeutic use Humans Male Randomized Controlled Trials as Topic Reactive Oxygen Species - toxicity Research Design Sodium Bicarbonate - therapeutic use |
| title | Lessons learned from the PRESERVE trial |
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