Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis
The prognostic value of tissue and serum osteopontin (OPN) in hepatocellular carcinoma (HCC) remain controversial. The aim of present meta-analysis was to evaluate the prognostic value of OPN in patients with HCC. Eligible studies were systematically searched by PubMed, EMBASE, and Google scholar. A...
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| Veröffentlicht in: | Medicine (Baltimore) 2018-10, Vol.97 (43), p.e12954-e12954 |
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| creator | Sun, Tingting Li, Peng Sun, Diwen Bu, Qingao Li, Guoqiang |
| description | The prognostic value of tissue and serum osteopontin (OPN) in hepatocellular carcinoma (HCC) remain controversial. The aim of present meta-analysis was to evaluate the prognostic value of OPN in patients with HCC.
Eligible studies were systematically searched by PubMed, EMBASE, and Google scholar. A meta-analysis of 12 studies included 2117 cases was performed to estimate the association between OPN level and overall survival (OS), disease-free survival (DFS) in HCC patients. Subgroup analyses were also performed in the meta-analysis.
The pooled data of studies showed that high OPN level was significantly associated with poor OS (hazard ratios [HR] 1.84; 95% confidence intervals [CI] 1.54-2.20; P = .000) and DFS (HR 1.67; 95% CI 1.40-1.98; P = .000) in HCC. Furthermore, in subgroup analysis, high tissue based OPN by immunohistochemistry detection and serum-based OPN by enzyme-linked immunosorbent assay (ELISA) detection were both significantly associated with OS (tissue: HR 1.88; 95% CI 1.53-2.31; P |
| doi_str_mv | 10.1097/MD.0000000000012954 |
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Eligible studies were systematically searched by PubMed, EMBASE, and Google scholar. A meta-analysis of 12 studies included 2117 cases was performed to estimate the association between OPN level and overall survival (OS), disease-free survival (DFS) in HCC patients. Subgroup analyses were also performed in the meta-analysis.
The pooled data of studies showed that high OPN level was significantly associated with poor OS (hazard ratios [HR] 1.84; 95% confidence intervals [CI] 1.54-2.20; P = .000) and DFS (HR 1.67; 95% CI 1.40-1.98; P = .000) in HCC. Furthermore, in subgroup analysis, high tissue based OPN by immunohistochemistry detection and serum-based OPN by enzyme-linked immunosorbent assay (ELISA) detection were both significantly associated with OS (tissue: HR 1.88; 95% CI 1.53-2.31; P < .0001; serum: HR 2.38; 95% CI 1.58-3.59; P < .0001). Simultaneously, we also found that OPN expression was positively associated with stage (odds ratios [OR] 5.68; 95% CI 3.443-7.758), tumor size (Size≤5 cm vs >5 cm; OR 2.001; 95% CI1.036-3.867).
The current evidence indicates that OPN could serve as a prognostic biomarker and a potential therapeutic target for HCC.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000012954</identifier><identifier>PMID: 30412113</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Biomarkers, Tumor - blood ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Disease-Free Survival ; Enzyme-Linked Immunosorbent Assay ; Humans ; Liver Neoplasms - blood ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Osteopontin - blood ; Prognosis ; Proportional Hazards Models ; Sensitivity and Specificity ; Systematic Review and Meta-Analysis</subject><ispartof>Medicine (Baltimore), 2018-10, Vol.97 (43), p.e12954-e12954</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3556-1bb08e9b48f4f869cda7e7f09edd7f31f55b8ab341578b1164a483df61f9d5c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221565/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221565/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30412113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Tingting</creatorcontrib><creatorcontrib>Li, Peng</creatorcontrib><creatorcontrib>Sun, Diwen</creatorcontrib><creatorcontrib>Bu, Qingao</creatorcontrib><creatorcontrib>Li, Guoqiang</creatorcontrib><title>Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The prognostic value of tissue and serum osteopontin (OPN) in hepatocellular carcinoma (HCC) remain controversial. The aim of present meta-analysis was to evaluate the prognostic value of OPN in patients with HCC.
Eligible studies were systematically searched by PubMed, EMBASE, and Google scholar. A meta-analysis of 12 studies included 2117 cases was performed to estimate the association between OPN level and overall survival (OS), disease-free survival (DFS) in HCC patients. Subgroup analyses were also performed in the meta-analysis.
The pooled data of studies showed that high OPN level was significantly associated with poor OS (hazard ratios [HR] 1.84; 95% confidence intervals [CI] 1.54-2.20; P = .000) and DFS (HR 1.67; 95% CI 1.40-1.98; P = .000) in HCC. Furthermore, in subgroup analysis, high tissue based OPN by immunohistochemistry detection and serum-based OPN by enzyme-linked immunosorbent assay (ELISA) detection were both significantly associated with OS (tissue: HR 1.88; 95% CI 1.53-2.31; P < .0001; serum: HR 2.38; 95% CI 1.58-3.59; P < .0001). Simultaneously, we also found that OPN expression was positively associated with stage (odds ratios [OR] 5.68; 95% CI 3.443-7.758), tumor size (Size≤5 cm vs >5 cm; OR 2.001; 95% CI1.036-3.867).
The current evidence indicates that OPN could serve as a prognostic biomarker and a potential therapeutic target for HCC.</description><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Disease-Free Survival</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Humans</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Osteopontin - blood</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Sensitivity and Specificity</subject><subject>Systematic Review and Meta-Analysis</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVtvFSEUhYnR2GP1F5gYHn2ZljuDDyZN66VJG33QZ8LMQAdlhhGYc3L-vRxPrRdCQjZ8a212FgAvMTrDSMnz26sz9Gdhojh7BDaYU9FwJdhjsEGI8EYqyU7As5y_VYhKwp6CE4oYJhjTDVg-p3g3x1x8D7cmrBZGB2tp4xLn4mdY92KKt3PJcOfLCEdb69jbENZgEuxN6v0cJ_MGXsC8r8rJHMyS3Xq7g2Ye4GSLacxswj77_Bw8cSZk--L-PAVf37_7cvmxufn04fry4qbpKeeiwV2HWqs61jrmWqH6wUgrHVJ2GKSj2HHetaajDHPZdhgLZlhLByewUwPvET0Fb4--y9pNdujrAMkEvSQ_mbTX0Xj978vsR30Xt1oQgrng1eD1vUGKP1abi558PoxtZhvXrAmmhBApkaooPaJ9ijkn6x7aYKQPWenbK_1_VlX16u8fPmh-h1MBdgR2MRSb8vew7mzSozWhjL_8uFSkIQi3GBGBmsONoD8BfuOiMw</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Sun, Tingting</creator><creator>Li, Peng</creator><creator>Sun, Diwen</creator><creator>Bu, Qingao</creator><creator>Li, Guoqiang</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181001</creationdate><title>Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis</title><author>Sun, Tingting ; Li, Peng ; Sun, Diwen ; Bu, Qingao ; Li, Guoqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3556-1bb08e9b48f4f869cda7e7f09edd7f31f55b8ab341578b1164a483df61f9d5c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Disease-Free Survival</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Humans</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Osteopontin - blood</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Sensitivity and Specificity</topic><topic>Systematic Review and Meta-Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Tingting</creatorcontrib><creatorcontrib>Li, Peng</creatorcontrib><creatorcontrib>Sun, Diwen</creatorcontrib><creatorcontrib>Bu, Qingao</creatorcontrib><creatorcontrib>Li, Guoqiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Tingting</au><au>Li, Peng</au><au>Sun, Diwen</au><au>Bu, Qingao</au><au>Li, Guoqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>97</volume><issue>43</issue><spage>e12954</spage><epage>e12954</epage><pages>e12954-e12954</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The prognostic value of tissue and serum osteopontin (OPN) in hepatocellular carcinoma (HCC) remain controversial. The aim of present meta-analysis was to evaluate the prognostic value of OPN in patients with HCC.
Eligible studies were systematically searched by PubMed, EMBASE, and Google scholar. A meta-analysis of 12 studies included 2117 cases was performed to estimate the association between OPN level and overall survival (OS), disease-free survival (DFS) in HCC patients. Subgroup analyses were also performed in the meta-analysis.
The pooled data of studies showed that high OPN level was significantly associated with poor OS (hazard ratios [HR] 1.84; 95% confidence intervals [CI] 1.54-2.20; P = .000) and DFS (HR 1.67; 95% CI 1.40-1.98; P = .000) in HCC. Furthermore, in subgroup analysis, high tissue based OPN by immunohistochemistry detection and serum-based OPN by enzyme-linked immunosorbent assay (ELISA) detection were both significantly associated with OS (tissue: HR 1.88; 95% CI 1.53-2.31; P < .0001; serum: HR 2.38; 95% CI 1.58-3.59; P < .0001). Simultaneously, we also found that OPN expression was positively associated with stage (odds ratios [OR] 5.68; 95% CI 3.443-7.758), tumor size (Size≤5 cm vs >5 cm; OR 2.001; 95% CI1.036-3.867).
The current evidence indicates that OPN could serve as a prognostic biomarker and a potential therapeutic target for HCC.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>30412113</pmid><doi>10.1097/MD.0000000000012954</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers, Tumor - blood Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Disease-Free Survival Enzyme-Linked Immunosorbent Assay Humans Liver Neoplasms - blood Liver Neoplasms - mortality Liver Neoplasms - pathology Osteopontin - blood Prognosis Proportional Hazards Models Sensitivity and Specificity Systematic Review and Meta-Analysis |
| title | Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis |
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