Endothelial Cell–Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature

OBJECTIVE—Blood-CNS barrier defects are implicated in retinopathies, neurodegenerative diseases, stroke, and epilepsy, yet, the pathological mechanisms downstream of barrier defects remain incompletely understood. Blood-retina barrier (BRB) formation and retinal angiogenesis require β-catenin signal...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-11, Vol.38 (11), p.2691-2705
Hauptverfasser:	Zhang, Chi, Lai, Maria B, Pedler, Michelle G, Johnson, Verity, Adams, Ralf H, Petrash, J Mark, Chen, Zhe, Junge, Harald J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Antigens, CD - genetics Antigens, CD - metabolism Basement Membrane - metabolism Basement Membrane - pathology Basic Sciences Blood-Retinal Barrier - immunology Blood-Retinal Barrier - metabolism Blood-Retinal Barrier - pathology Cadherins - genetics Cadherins - metabolism Cell Proliferation Cellular Senescence Complement System Proteins - immunology Complement System Proteins - metabolism Diabetic Retinopathy - genetics Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - pathology Eye Diseases, Hereditary - genetics Eye Diseases, Hereditary - metabolism Eye Diseases, Hereditary - pathology Familial Exudative Vitreoretinopathies Female Genotype Immunoglobulins - immunology Immunoglobulins - metabolism Macular Edema - genetics Macular Edema - metabolism Macular Edema - pathology Male Mice, Knockout Phenotype Retinal Diseases - genetics Retinal Diseases - metabolism Retinal Diseases - pathology Retinal Neovascularization Retinal Vessels - immunology Retinal Vessels - metabolism Retinal Vessels - pathology Signal Transduction Tetraspanins - deficiency Tetraspanins - genetics
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