Case Report: Monoclonal Gammopathy of Undetermined Significance is Associated with Loa loa Infection
A 63-year-old woman who migrated from Nigeria to the United States was found to have an elevated total serum protein, anemia, and eosinophilia. Serum protein electrophoresis (SPEP) and serum protein immunofixation electrophoresis (SPIFE) demonstrated monoclonal immunoglobulin G (IgG) κ restricted ba...
Gespeichert in:
| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2018-01, Vol.99 (5), p.1206-1210 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1210 |
|---|---|
| container_issue | 5 |
| container_start_page | 1206 |
| container_title | The American journal of tropical medicine and hygiene |
| container_volume | 99 |
| creator | Laskar, Derek B Rose, Michael Gupta, Raavi Tanowitz, Herbert B Haseeb, M A |
| description | A 63-year-old woman who migrated from Nigeria to the United States was found to have an elevated total serum protein, anemia, and eosinophilia. Serum protein electrophoresis (SPEP) and serum protein immunofixation electrophoresis (SPIFE) demonstrated monoclonal immunoglobulin G (IgG) κ restricted bands (IgG 3,820 mg/dL; κ/λ ratio 4.47), indicative of monoclonal gammopathy of unknown significance (MGUS). A rapid diagnostic test (RDT) for malaria was positive for
(BinaxNOW
; Alere Scarborough Inc., Scarborough, ME). Giemsa-stained blood smears were negative for malarial parasites, however,
microfilariae were identified. Reverse transcription polymerase chain reaction for
,
,
, and
yielded a negative result. She was treated for loiasis with diethylcarbamazine and received no malaria medication. Treatment resulted in a resolution of the microfilaremia and eosinophilia, a negative RDT for malaria, and marked reduction in the monoclonal gammopathy. This is the first reported human case of MGUS associated with loiasis and its resolution after antiparasitic treatment. |
| doi_str_mv | 10.4269/ajtmh.18-0351 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6221212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2102319680</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-534860bc49226d0160329ae6d49959bc0fe55a6d8fd43f933742daee5ec720523</originalsourceid><addsrcrecordid>eNpdkc1rGzEQxUVJady0x16LIJdeNtH3rnIIGNOmAZdA2pyFLM3GMruSI8kp-e-7btLQhGGYw_x4zJuH0CdKTgRT-tRu6rg-oV1DuKRv0IyKVjVUCXmAZoQQ1mjF20P0vpQNIbRjlL5Dh5wwwlvBZ8gvbAF8DduU6xn-kWJyQ4p2wBd2HNPW1vUDTj2-iR4q5DFE8PhnuI2hD85GBzgUPC8luWDrtPod6hovk8XD1JexB1dDih_Q294OBT4-zSN08-3rr8X3Znl1cbmYLxsnqKyN5KJTZOWEZkx5QhXhTFtQXmgt9cqRHqS0yne9F7zXfHLAvAWQ4FpGJONH6PxRd7tbjeAdxJrtYLY5jDY_mGSDebmJYW1u071RjNGpJoEvTwI53e2gVDOG4mAYbIS0K4ZRwjjVqiMTevwK3aRdnj63pxRlbSe6vWDzSLmcSsnQPx9DidnnZ_7mZ2hn9vlN_Of_HTzT_wLjfwDBRJdm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2161278482</pqid></control><display><type>article</type><title>Case Report: Monoclonal Gammopathy of Undetermined Significance is Associated with Loa loa Infection</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Laskar, Derek B ; Rose, Michael ; Gupta, Raavi ; Tanowitz, Herbert B ; Haseeb, M A</creator><creatorcontrib>Laskar, Derek B ; Rose, Michael ; Gupta, Raavi ; Tanowitz, Herbert B ; Haseeb, M A</creatorcontrib><description>A 63-year-old woman who migrated from Nigeria to the United States was found to have an elevated total serum protein, anemia, and eosinophilia. Serum protein electrophoresis (SPEP) and serum protein immunofixation electrophoresis (SPIFE) demonstrated monoclonal immunoglobulin G (IgG) κ restricted bands (IgG 3,820 mg/dL; κ/λ ratio 4.47), indicative of monoclonal gammopathy of unknown significance (MGUS). A rapid diagnostic test (RDT) for malaria was positive for
(BinaxNOW
; Alere Scarborough Inc., Scarborough, ME). Giemsa-stained blood smears were negative for malarial parasites, however,
microfilariae were identified. Reverse transcription polymerase chain reaction for
,
,
, and
yielded a negative result. She was treated for loiasis with diethylcarbamazine and received no malaria medication. Treatment resulted in a resolution of the microfilaremia and eosinophilia, a negative RDT for malaria, and marked reduction in the monoclonal gammopathy. This is the first reported human case of MGUS associated with loiasis and its resolution after antiparasitic treatment.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.18-0351</identifier><identifier>PMID: 30203743</identifier><language>eng</language><publisher>United States: Institute of Tropical Medicine</publisher><subject>Animals ; Antiparasitic Agents - therapeutic use ; Case reports ; Erythrocytes ; Female ; Humans ; Loa - drug effects ; Loiasis - complications ; Loiasis - drug therapy ; Malaria ; Malaria, Falciparum - diagnosis ; Microfilariae - isolation & purification ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance - diagnosis ; Monoclonal Gammopathy of Undetermined Significance - parasitology ; Plasmodium falciparum - isolation & purification ; Proteins ; Treatment Outcome</subject><ispartof>The American journal of tropical medicine and hygiene, 2018-01, Vol.99 (5), p.1206-1210</ispartof><rights>Copyright Institute of Tropical Medicine 2018</rights><rights>The American Society of Tropical Medicine and Hygiene 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-534860bc49226d0160329ae6d49959bc0fe55a6d8fd43f933742daee5ec720523</citedby><cites>FETCH-LOGICAL-c415t-534860bc49226d0160329ae6d49959bc0fe55a6d8fd43f933742daee5ec720523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221212/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221212/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30203743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laskar, Derek B</creatorcontrib><creatorcontrib>Rose, Michael</creatorcontrib><creatorcontrib>Gupta, Raavi</creatorcontrib><creatorcontrib>Tanowitz, Herbert B</creatorcontrib><creatorcontrib>Haseeb, M A</creatorcontrib><title>Case Report: Monoclonal Gammopathy of Undetermined Significance is Associated with Loa loa Infection</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>A 63-year-old woman who migrated from Nigeria to the United States was found to have an elevated total serum protein, anemia, and eosinophilia. Serum protein electrophoresis (SPEP) and serum protein immunofixation electrophoresis (SPIFE) demonstrated monoclonal immunoglobulin G (IgG) κ restricted bands (IgG 3,820 mg/dL; κ/λ ratio 4.47), indicative of monoclonal gammopathy of unknown significance (MGUS). A rapid diagnostic test (RDT) for malaria was positive for
(BinaxNOW
; Alere Scarborough Inc., Scarborough, ME). Giemsa-stained blood smears were negative for malarial parasites, however,
microfilariae were identified. Reverse transcription polymerase chain reaction for
,
,
, and
yielded a negative result. She was treated for loiasis with diethylcarbamazine and received no malaria medication. Treatment resulted in a resolution of the microfilaremia and eosinophilia, a negative RDT for malaria, and marked reduction in the monoclonal gammopathy. This is the first reported human case of MGUS associated with loiasis and its resolution after antiparasitic treatment.</description><subject>Animals</subject><subject>Antiparasitic Agents - therapeutic use</subject><subject>Case reports</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Humans</subject><subject>Loa - drug effects</subject><subject>Loiasis - complications</subject><subject>Loiasis - drug therapy</subject><subject>Malaria</subject><subject>Malaria, Falciparum - diagnosis</subject><subject>Microfilariae - isolation & purification</subject><subject>Middle Aged</subject><subject>Monoclonal Gammopathy of Undetermined Significance - diagnosis</subject><subject>Monoclonal Gammopathy of Undetermined Significance - parasitology</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Proteins</subject><subject>Treatment Outcome</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1rGzEQxUVJady0x16LIJdeNtH3rnIIGNOmAZdA2pyFLM3GMruSI8kp-e-7btLQhGGYw_x4zJuH0CdKTgRT-tRu6rg-oV1DuKRv0IyKVjVUCXmAZoQQ1mjF20P0vpQNIbRjlL5Dh5wwwlvBZ8gvbAF8DduU6xn-kWJyQ4p2wBd2HNPW1vUDTj2-iR4q5DFE8PhnuI2hD85GBzgUPC8luWDrtPod6hovk8XD1JexB1dDih_Q294OBT4-zSN08-3rr8X3Znl1cbmYLxsnqKyN5KJTZOWEZkx5QhXhTFtQXmgt9cqRHqS0yne9F7zXfHLAvAWQ4FpGJONH6PxRd7tbjeAdxJrtYLY5jDY_mGSDebmJYW1u071RjNGpJoEvTwI53e2gVDOG4mAYbIS0K4ZRwjjVqiMTevwK3aRdnj63pxRlbSe6vWDzSLmcSsnQPx9DidnnZ_7mZ2hn9vlN_Of_HTzT_wLjfwDBRJdm</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Laskar, Derek B</creator><creator>Rose, Michael</creator><creator>Gupta, Raavi</creator><creator>Tanowitz, Herbert B</creator><creator>Haseeb, M A</creator><general>Institute of Tropical Medicine</general><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Case Report: Monoclonal Gammopathy of Undetermined Significance is Associated with Loa loa Infection</title><author>Laskar, Derek B ; Rose, Michael ; Gupta, Raavi ; Tanowitz, Herbert B ; Haseeb, M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-534860bc49226d0160329ae6d49959bc0fe55a6d8fd43f933742daee5ec720523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antiparasitic Agents - therapeutic use</topic><topic>Case reports</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Humans</topic><topic>Loa - drug effects</topic><topic>Loiasis - complications</topic><topic>Loiasis - drug therapy</topic><topic>Malaria</topic><topic>Malaria, Falciparum - diagnosis</topic><topic>Microfilariae - isolation & purification</topic><topic>Middle Aged</topic><topic>Monoclonal Gammopathy of Undetermined Significance - diagnosis</topic><topic>Monoclonal Gammopathy of Undetermined Significance - parasitology</topic><topic>Plasmodium falciparum - isolation & purification</topic><topic>Proteins</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laskar, Derek B</creatorcontrib><creatorcontrib>Rose, Michael</creatorcontrib><creatorcontrib>Gupta, Raavi</creatorcontrib><creatorcontrib>Tanowitz, Herbert B</creatorcontrib><creatorcontrib>Haseeb, M A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laskar, Derek B</au><au>Rose, Michael</au><au>Gupta, Raavi</au><au>Tanowitz, Herbert B</au><au>Haseeb, M A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case Report: Monoclonal Gammopathy of Undetermined Significance is Associated with Loa loa Infection</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>99</volume><issue>5</issue><spage>1206</spage><epage>1210</epage><pages>1206-1210</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><abstract>A 63-year-old woman who migrated from Nigeria to the United States was found to have an elevated total serum protein, anemia, and eosinophilia. Serum protein electrophoresis (SPEP) and serum protein immunofixation electrophoresis (SPIFE) demonstrated monoclonal immunoglobulin G (IgG) κ restricted bands (IgG 3,820 mg/dL; κ/λ ratio 4.47), indicative of monoclonal gammopathy of unknown significance (MGUS). A rapid diagnostic test (RDT) for malaria was positive for
(BinaxNOW
; Alere Scarborough Inc., Scarborough, ME). Giemsa-stained blood smears were negative for malarial parasites, however,
microfilariae were identified. Reverse transcription polymerase chain reaction for
,
,
, and
yielded a negative result. She was treated for loiasis with diethylcarbamazine and received no malaria medication. Treatment resulted in a resolution of the microfilaremia and eosinophilia, a negative RDT for malaria, and marked reduction in the monoclonal gammopathy. This is the first reported human case of MGUS associated with loiasis and its resolution after antiparasitic treatment.</abstract><cop>United States</cop><pub>Institute of Tropical Medicine</pub><pmid>30203743</pmid><doi>10.4269/ajtmh.18-0351</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9637 |
| ispartof | The American journal of tropical medicine and hygiene, 2018-01, Vol.99 (5), p.1206-1210 |
| issn | 0002-9637 1476-1645 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6221212 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antiparasitic Agents - therapeutic use Case reports Erythrocytes Female Humans Loa - drug effects Loiasis - complications Loiasis - drug therapy Malaria Malaria, Falciparum - diagnosis Microfilariae - isolation & purification Middle Aged Monoclonal Gammopathy of Undetermined Significance - diagnosis Monoclonal Gammopathy of Undetermined Significance - parasitology Plasmodium falciparum - isolation & purification Proteins Treatment Outcome |
| title | Case Report: Monoclonal Gammopathy of Undetermined Significance is Associated with Loa loa Infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A38%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Case%20Report:%20Monoclonal%20Gammopathy%20of%20Undetermined%20Significance%20is%20Associated%20with%20Loa%20loa%20Infection&rft.jtitle=The%20American%20journal%20of%20tropical%20medicine%20and%20hygiene&rft.au=Laskar,%20Derek%20B&rft.date=2018-01-01&rft.volume=99&rft.issue=5&rft.spage=1206&rft.epage=1210&rft.pages=1206-1210&rft.issn=0002-9637&rft.eissn=1476-1645&rft_id=info:doi/10.4269/ajtmh.18-0351&rft_dat=%3Cproquest_pubme%3E2102319680%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2161278482&rft_id=info:pmid/30203743&rfr_iscdi=true |