Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

ABSTRACT Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear cells in recently diagnosed PD patien...

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Veröffentlicht in:	Movement disorders 2018-10, Vol.33 (10), p.1580-1590
Hauptverfasser:	Smith, Amy M., Depp, Constanze, Ryan, Brent J., Johnston, Geoffrey I., Alegre‐Abarrategui, Javier, Evetts, Samuel, Rolinski, Michal, Baig, Fahd, Ruffmann, Claudio, Simon, Anna Katharina, Hu, Michele T. M., Wade‐Martins, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Cytokines - metabolism Electron Transport Complex IV - metabolism Enzyme Inhibitors - pharmacology Female Flow Cytometry Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Glucose - metabolism Glucose Transporter Type 1 - metabolism glycolysis Glycolysis - physiology Humans Leukocytes, Mononuclear - ultrastructure Male Mitochondria - metabolism Mitochondria - pathology Mitochondrial Diseases - etiology mitochondrial dysfunction Oxygen Consumption - physiology Parkinson Disease - blood Parkinson Disease - complications Parkinson Disease - pathology Parkinson's disease peripheral blood mononuclear cells Prodromal Symptoms Reactive Oxygen Species - metabolism Receptors, CCR2 - metabolism REM Sleep Behavior Disorder - blood REM Sleep Behavior Disorder - complications REM Sleep Behavior Disorder - pathology REM‐sleep behavior disorder RNA, Messenger - metabolism Superoxide Dismutase - genetics Superoxide Dismutase - metabolism
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