Structure of a human synaptic GABA A receptor

Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABA receptor). Dysfunction of this receptor results in neurological disorders and mental illnesses including epilepsy, anxiety...

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Veröffentlicht in:	Nature (London) 2018-07, Vol.559 (7712), p.67-72
Hauptverfasser:	Zhu, Shaotong, Noviello, Colleen M, Teng, Jinfeng, Walsh, Jr, Richard M, Kim, Jeong Joo, Hibbs, Ryan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzodiazepines - antagonists & inhibitors Benzodiazepines - chemistry Benzodiazepines - metabolism Benzodiazepines - pharmacology Bicuculline - pharmacology Binding, Competitive - drug effects Brain Chemistry Cell Membrane - chemistry Cell Membrane - metabolism Cryoelectron Microscopy Flumazenil - chemistry Flumazenil - metabolism Flumazenil - pharmacology GABA Modulators - chemistry GABA Modulators - metabolism GABA Modulators - pharmacology gamma-Aminobutyric Acid - chemistry gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacology Glycosylation HEK293 Cells Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology Ligands Models, Molecular Receptors, GABA-A - chemistry Receptors, GABA-A - immunology Receptors, GABA-A - metabolism Receptors, GABA-A - ultrastructure
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