Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach

Due to the rudimentary antioxidant defenses in Trypanosoma cruzi, disruptors of redox balance are promising candidates for new antitrypanosomal drugs. We developed an integrated model based on systematic review, meta-analyses, and molecular modeling to evaluate the effect of trypanothione reductase...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-20
Hauptverfasser:	Novaes, Rômulo Dias, Teixeira, Antonio Lucio, Gonçalves, Reggiani Vilela, Caldas, Ivo Santana, Veloso, Marcia Paranho, Coelho, Camila Morais, Santos Mendonça, Andréia Aparecida, de Miranda, Aline Silva
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Binding sites Cardiomyopathy Congenital diseases Drugs Enzyme inhibitors Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Health aspects Heart failure Humans Infection Infections Integrated approach Medical research Medicine, Experimental Meta-analysis Mice, Inbred BALB C NADH, NADPH Oxidoreductases - antagonists & inhibitors Parasites Parasitic diseases R&D Research & development Review Systematic review Thioridazine Transplants & implants Tropical diseases Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Trypanosoma cruzi - pathogenicity
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