The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome

Proline-rich antimicrobial peptides (PrAMPs) internalize into susceptible bacteria using specific transporters and interfere with protein synthesis and folding. To date, mammalian PrAMPs have so far been identified only in artiodactyls. Since cetaceans are co-phyletic with artiodactyls, we mined the...

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Veröffentlicht in:	Cell chemical biology 2018-05, Vol.25 (5), p.530-539.e7
Hauptverfasser:	Mardirossian, Mario, Pérébaskine, Natacha, Benincasa, Monica, Gambato, Stefano, Hofmann, Sven, Huter, Paul, Müller, Claudia, Hilpert, Kai, Innis, C. Axel, Tossi, Alessandro, Wilson, Daniel N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibiotic Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Bac7 cathelicidin Crystallography, X-Ray dolphin Dolphins Escherichia coli - drug effects Escherichia coli - metabolism Escherichia coli Infections - drug therapy Escherichia coli Proteins - metabolism Humans Models, Molecular PrAMP proline-rich antimicrobial peptide Protein Biosynthesis - drug effects ribosome Ribosomes - drug effects Ribosomes - metabolism Tur1A Tur1B
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