GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing

Malaria is caused by parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito vector and transmit malaria. Sexual commitment is triggered by activation of AP2-G, the master transcriptional...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-03, Vol.359 (6381), p.1259-1263
Hauptverfasser:	Filarsky, Michael, Fraschka, Sabine A, Niederwieser, Igor, Brancucci, Nicolas M B, Carrington, Eilidh, Carrió, Elvira, Moes, Suzette, Jenoe, Paul, Bártfai, Richárd, Voss, Till S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense RNA Aquatic insects Chromobox Protein Homolog 5 Chromosomal Proteins, Non-Histone - metabolism Disease transmission Gametes Gametocytes Gametogenesis - genetics Gene expression Gene Silencing Heterochromatin Heterochromatin protein 1 Individualized Instruction Malaria Malaria, Falciparum - parasitology Mosquitoes Parasites Plasmodium Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Proteins Replication Ribonucleic acid RNA Sex differentiation Sex Differentiation - genetics Sex Education Tissues Transcription Vector-borne diseases
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