Epigenetic mechanisms in the placenta related to infant neurodevelopment
As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant neurodevelopment. We described the characteristics and findings of the 17 studies on epigenetic processes in placental genes...
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| Veröffentlicht in: | Epigenomics 2018-03, Vol.10 (3), p.321-333 |
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| creator | Lester, Barry M Marsit, Carmen J |
| description | As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant neurodevelopment. We described the characteristics and findings of the 17 studies on epigenetic processes in placental genes and human infant neurobehavior. Studies showed consistent findings in the same cohort of term healthy infants across epigenetic processes (DNA methylation, genome wide, gene and miRNA expression) genomic region (single and multiple genes, imprinted genes and miRNAs) using candidate gene and genome wide approaches and across biobehavioral systems (neurobehavior, cry acoustics and neuroendocrine). Despite limitations, studies support future work on molecular processes in placental genes related to neurodevelopmental trajectories including implications for intervention. |
| doi_str_mv | 10.2217/epi-2016-0171 |
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We described the characteristics and findings of the 17 studies on epigenetic processes in placental genes and human infant neurobehavior. Studies showed consistent findings in the same cohort of term healthy infants across epigenetic processes (DNA methylation, genome wide, gene and miRNA expression) genomic region (single and multiple genes, imprinted genes and miRNAs) using candidate gene and genome wide approaches and across biobehavioral systems (neurobehavior, cry acoustics and neuroendocrine). Despite limitations, studies support future work on molecular processes in placental genes related to neurodevelopmental trajectories including implications for intervention.</description><identifier>ISSN: 1750-1911</identifier><identifier>EISSN: 1750-192X</identifier><identifier>DOI: 10.2217/epi-2016-0171</identifier><identifier>PMID: 29381081</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Acoustics ; Arousal - genetics ; Attention - physiology ; Behavior ; Brain ; Brain - growth & development ; Brain - metabolism ; Brain research ; Cardiovascular disease ; Cell division ; CpG Islands ; cry acoustics ; Deoxyribonucleic acid ; development ; DNA ; DNA Methylation ; Epigenesis, Genetic ; Epigenetics ; Female ; Fetal Development - genetics ; fetal programming ; Fetus ; Fetuses ; Gene expression ; Genes ; Genome, Human ; Genomes ; Hormones ; HPA axis ; Humans ; Infant ; Infant Behavior - physiology ; Infants ; Lethargy - genetics ; Lethargy - metabolism ; Lethargy - physiopathology ; Metabolism ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Motor Activity - genetics ; neurobehavior ; Neurodevelopment ; Neurogenesis - genetics ; Neurosecretory Systems - growth & development ; Neurosecretory Systems - metabolism ; NICU network neurobehavioral scale (NNNS) ; Pediatrics ; Placenta ; Placenta - metabolism ; Pregnancy ; Review ; trajectories</subject><ispartof>Epigenomics, 2018-03, Vol.10 (3), p.321-333</ispartof><rights>2018 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Mar 2018</rights><rights>2018 Future Medicine Ltd 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-a7408ef909ffd2f4e01deef24e21e1e520642db6ca0f9cac9f2ce75b0b4425b63</citedby><cites>FETCH-LOGICAL-c465t-a7408ef909ffd2f4e01deef24e21e1e520642db6ca0f9cac9f2ce75b0b4425b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219448/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219448/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29381081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lester, Barry M</creatorcontrib><creatorcontrib>Marsit, Carmen J</creatorcontrib><title>Epigenetic mechanisms in the placenta related to infant neurodevelopment</title><title>Epigenomics</title><addtitle>Epigenomics</addtitle><description>As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant neurodevelopment. We described the characteristics and findings of the 17 studies on epigenetic processes in placental genes and human infant neurobehavior. Studies showed consistent findings in the same cohort of term healthy infants across epigenetic processes (DNA methylation, genome wide, gene and miRNA expression) genomic region (single and multiple genes, imprinted genes and miRNAs) using candidate gene and genome wide approaches and across biobehavioral systems (neurobehavior, cry acoustics and neuroendocrine). Despite limitations, studies support future work on molecular processes in placental genes related to neurodevelopmental trajectories including implications for intervention.</description><subject>Acoustics</subject><subject>Arousal - genetics</subject><subject>Attention - physiology</subject><subject>Behavior</subject><subject>Brain</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Cardiovascular disease</subject><subject>Cell division</subject><subject>CpG Islands</subject><subject>cry acoustics</subject><subject>Deoxyribonucleic acid</subject><subject>development</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Fetal Development - genetics</subject><subject>fetal programming</subject><subject>Fetus</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Hormones</subject><subject>HPA axis</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Behavior - physiology</subject><subject>Infants</subject><subject>Lethargy - genetics</subject><subject>Lethargy - metabolism</subject><subject>Lethargy - physiopathology</subject><subject>Metabolism</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Motor Activity - genetics</subject><subject>neurobehavior</subject><subject>Neurodevelopment</subject><subject>Neurogenesis - genetics</subject><subject>Neurosecretory Systems - growth & development</subject><subject>Neurosecretory Systems - metabolism</subject><subject>NICU network neurobehavioral scale (NNNS)</subject><subject>Pediatrics</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Review</subject><subject>trajectories</subject><issn>1750-1911</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM9LBCEYhiWKiurYNQY6T_k5zg8vQUS1QdCloJs4zueuMeNM6gT997lsLXXIi8r3-PryEHIK9IIxqC9xsjmjUOUUatghh1CXNAfBXne3Z4ADchLCG02rYI2oYJ8cMFE0QBs4JIvbyS7RYbQ6G1CvlLNhCJl1WVxhNvVKo4sq89iriF0WxzQyysXM4ezHDj-wH6chMcdkz6g-4Mn3fkRe7m6fbxb549P9w831Y655VcZc1Zw2aAQVxnTMcKTQIRrGkQECloxWnHVtpRU1QistDNNYly1tOWdlWxVH5GqTO83tgN26nle9nLwdlP-Uo7Ly78TZlVyOH7JiIDhvUsD5d4Af32cMUb6Ns3eps0xOq7IoCkETlW8o7ccQPJrtD0DXXC2Te7l2L9fuE3_2u9aW_jGdALEBzBxnj0FbdBrl5pZeWG0d_hP-BS7BlSk</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Lester, Barry M</creator><creator>Marsit, Carmen J</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20180301</creationdate><title>Epigenetic mechanisms in the placenta related to infant neurodevelopment</title><author>Lester, Barry M ; Marsit, Carmen J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-a7408ef909ffd2f4e01deef24e21e1e520642db6ca0f9cac9f2ce75b0b4425b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acoustics</topic><topic>Arousal - genetics</topic><topic>Attention - physiology</topic><topic>Behavior</topic><topic>Brain</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brain research</topic><topic>Cardiovascular disease</topic><topic>Cell division</topic><topic>CpG Islands</topic><topic>cry acoustics</topic><topic>Deoxyribonucleic acid</topic><topic>development</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Fetal Development - genetics</topic><topic>fetal programming</topic><topic>Fetus</topic><topic>Fetuses</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Hormones</topic><topic>HPA axis</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Behavior - physiology</topic><topic>Infants</topic><topic>Lethargy - genetics</topic><topic>Lethargy - metabolism</topic><topic>Lethargy - physiopathology</topic><topic>Metabolism</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>Motor Activity - genetics</topic><topic>neurobehavior</topic><topic>Neurodevelopment</topic><topic>Neurogenesis - genetics</topic><topic>Neurosecretory Systems - growth & development</topic><topic>Neurosecretory Systems - metabolism</topic><topic>NICU network neurobehavioral scale (NNNS)</topic><topic>Pediatrics</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Review</topic><topic>trajectories</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lester, Barry M</creatorcontrib><creatorcontrib>Marsit, Carmen J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lester, Barry M</au><au>Marsit, Carmen J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigenetic mechanisms in the placenta related to infant neurodevelopment</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>10</volume><issue>3</issue><spage>321</spage><epage>333</epage><pages>321-333</pages><issn>1750-1911</issn><eissn>1750-192X</eissn><abstract>As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant neurodevelopment. 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| subjects | Acoustics Arousal - genetics Attention - physiology Behavior Brain Brain - growth & development Brain - metabolism Brain research Cardiovascular disease Cell division CpG Islands cry acoustics Deoxyribonucleic acid development DNA DNA Methylation Epigenesis, Genetic Epigenetics Female Fetal Development - genetics fetal programming Fetus Fetuses Gene expression Genes Genome, Human Genomes Hormones HPA axis Humans Infant Infant Behavior - physiology Infants Lethargy - genetics Lethargy - metabolism Lethargy - physiopathology Metabolism MicroRNAs - genetics MicroRNAs - metabolism miRNA Motor Activity - genetics neurobehavior Neurodevelopment Neurogenesis - genetics Neurosecretory Systems - growth & development Neurosecretory Systems - metabolism NICU network neurobehavioral scale (NNNS) Pediatrics Placenta Placenta - metabolism Pregnancy Review trajectories |
| title | Epigenetic mechanisms in the placenta related to infant neurodevelopment |
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