Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model

Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2018-12, Vol.117, p.149-160
Hauptverfasser:	Logan, Niall J., Camman, Marie, Williams, Greg, Higgins, Claire A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blast Injuries - genetics Blast Injuries - pathology Blast overpressure exposure Calcification, Physiologic - genetics Cell Culture Techniques Cell Differentiation Cell Nucleus - pathology Demethylation DNA Methylation Epigenetic DNA methylation Heterotopic ossification High-Energy Shock Waves Humans In vitro model Integrin alphaV - metabolism Models, Biological Ossification Ossification, Heterotopic - pathology Osteogenesis Promoter Regions, Genetic - genetics
Online-Zugang:	Volltext
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