Selection and Plasmid Transfer Underlie Adaptive Mutation in Escherichia coli

In the Cairns-Foster adaptive mutation system, a +1 frameshift mutant of is plated on lactose medium, where the nondividing population gives rise to Lac revertant colonies during a week under selection. Reversion requires the mutant allele to be located on a conjugative F' plasmid that also enc...

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