Bacterial Extracellular DNA Production Is Associated with Outcome of Prosthetic Joint Infections
In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hou...
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| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-6 |
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| creator | Presterl, Elisabeth Segagni Lusignani, Luigi Haffner, Nicolas Arciola, Carla Renata Zatorska, Beata Diab-Elschahawi, Magda |
| description | In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staphylococcal isolates (Staphylococcus aureus n=30, Staphylococcus epidermidis n=30) was correlated with the patients’ clinical outcome after 3 and 12 months. Statistical analysis was performed using either the Spearman’s rank correlations test or the t-test. eDNA production of S. epidermidis in 24-hour biofilms correlated with the patients’ outcome ‘not cured‘ after 12 months. For S. aureus no such correlation was detected. Thus, eDNA may be a virulence factor of S. epidermidis. Quantification of eDNA production as a surrogate marker for biofilm formation might be a potential predictive marker for the management of PJI. |
| doi_str_mv | 10.1155/2018/1067413 |
| format | Article |
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Data from a previous study on eDNA production determined in 24-hour biofilms of staphylococcal isolates (Staphylococcus aureus n=30, Staphylococcus epidermidis n=30) was correlated with the patients’ clinical outcome after 3 and 12 months. Statistical analysis was performed using either the Spearman’s rank correlations test or the t-test. eDNA production of S. epidermidis in 24-hour biofilms correlated with the patients’ outcome ‘not cured‘ after 12 months. For S. aureus no such correlation was detected. Thus, eDNA may be a virulence factor of S. epidermidis. Quantification of eDNA production as a surrogate marker for biofilm formation might be a potential predictive marker for the management of PJI.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/1067413</identifier><identifier>PMID: 30426000</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Analysis ; Antibiotics ; Antimicrobial agents ; Bacteria ; Bacterial genetics ; Biofilms ; Bone surgery ; Chemotherapy ; Classification ; Clinical outcomes ; Comorbidity ; Deoxyribonucleic acid ; DNA ; DNA, Bacterial - metabolism ; Drug resistance ; Environmental DNA ; Female ; Humans ; Implants, Artificial ; Infections ; Joint diseases ; Joint Prosthesis - microbiology ; Joint surgery ; Male ; Methicillin ; Middle Aged ; Mupirocin ; Pathogens ; Patient outcomes ; Patients ; Prostheses ; Prosthesis ; Rankings ; Retrospective Studies ; Staphylococcal Infections - metabolism ; Staphylococcus aureus ; Staphylococcus aureus - isolation & purification ; Staphylococcus aureus - pathogenicity ; Staphylococcus aureus - physiology ; Staphylococcus aureus infections ; Staphylococcus epidermidis ; Staphylococcus epidermidis - isolation & purification ; Staphylococcus epidermidis - pathogenicity ; Staphylococcus epidermidis - physiology ; Staphylococcus infections ; Statistical analysis ; Tetracycline ; Tetracyclines ; Virulence ; Virulence factors ; Virulence Factors - metabolism</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-6</ispartof><rights>Copyright © 2018 Beata Zatorska et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Beata Zatorska et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Beata Zatorska et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-e2dfe9f6a850a0ea44d36ab07baa28dbcea219fa3f33b2fdfa06d7561405d42c3</citedby><cites>FETCH-LOGICAL-c499t-e2dfe9f6a850a0ea44d36ab07baa28dbcea219fa3f33b2fdfa06d7561405d42c3</cites><orcidid>0000-0003-0382-0066 ; 0000-0003-1964-5434</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217901/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217901/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30426000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fink, Bernd</contributor><contributor>Bernd Fink</contributor><creatorcontrib>Presterl, Elisabeth</creatorcontrib><creatorcontrib>Segagni Lusignani, Luigi</creatorcontrib><creatorcontrib>Haffner, Nicolas</creatorcontrib><creatorcontrib>Arciola, Carla Renata</creatorcontrib><creatorcontrib>Zatorska, Beata</creatorcontrib><creatorcontrib>Diab-Elschahawi, Magda</creatorcontrib><title>Bacterial Extracellular DNA Production Is Associated with Outcome of Prosthetic Joint Infections</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staphylococcal isolates (Staphylococcus aureus n=30, Staphylococcus epidermidis n=30) was correlated with the patients’ clinical outcome after 3 and 12 months. Statistical analysis was performed using either the Spearman’s rank correlations test or the t-test. eDNA production of S. epidermidis in 24-hour biofilms correlated with the patients’ outcome ‘not cured‘ after 12 months. For S. aureus no such correlation was detected. Thus, eDNA may be a virulence factor of S. epidermidis. Quantification of eDNA production as a surrogate marker for biofilm formation might be a potential predictive marker for the management of PJI.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Bacterial genetics</subject><subject>Biofilms</subject><subject>Bone surgery</subject><subject>Chemotherapy</subject><subject>Classification</subject><subject>Clinical outcomes</subject><subject>Comorbidity</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Bacterial - metabolism</subject><subject>Drug resistance</subject><subject>Environmental DNA</subject><subject>Female</subject><subject>Humans</subject><subject>Implants, Artificial</subject><subject>Infections</subject><subject>Joint diseases</subject><subject>Joint Prosthesis - microbiology</subject><subject>Joint surgery</subject><subject>Male</subject><subject>Methicillin</subject><subject>Middle Aged</subject><subject>Mupirocin</subject><subject>Pathogens</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prostheses</subject><subject>Prosthesis</subject><subject>Rankings</subject><subject>Retrospective Studies</subject><subject>Staphylococcal Infections - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Presterl, Elisabeth</au><au>Segagni Lusignani, Luigi</au><au>Haffner, Nicolas</au><au>Arciola, Carla Renata</au><au>Zatorska, Beata</au><au>Diab-Elschahawi, Magda</au><au>Fink, Bernd</au><au>Bernd Fink</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial Extracellular DNA Production Is Associated with Outcome of Prosthetic Joint Infections</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staphylococcal isolates (Staphylococcus aureus n=30, Staphylococcus epidermidis n=30) was correlated with the patients’ clinical outcome after 3 and 12 months. Statistical analysis was performed using either the Spearman’s rank correlations test or the t-test. eDNA production of S. epidermidis in 24-hour biofilms correlated with the patients’ outcome ‘not cured‘ after 12 months. For S. aureus no such correlation was detected. Thus, eDNA may be a virulence factor of S. epidermidis. Quantification of eDNA production as a surrogate marker for biofilm formation might be a potential predictive marker for the management of PJI.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30426000</pmid><doi>10.1155/2018/1067413</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0382-0066</orcidid><orcidid>https://orcid.org/0000-0003-1964-5434</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Aged Aged, 80 and over Analysis Antibiotics Antimicrobial agents Bacteria Bacterial genetics Biofilms Bone surgery Chemotherapy Classification Clinical outcomes Comorbidity Deoxyribonucleic acid DNA DNA, Bacterial - metabolism Drug resistance Environmental DNA Female Humans Implants, Artificial Infections Joint diseases Joint Prosthesis - microbiology Joint surgery Male Methicillin Middle Aged Mupirocin Pathogens Patient outcomes Patients Prostheses Prosthesis Rankings Retrospective Studies Staphylococcal Infections - metabolism Staphylococcus aureus Staphylococcus aureus - isolation & purification Staphylococcus aureus - pathogenicity Staphylococcus aureus - physiology Staphylococcus aureus infections Staphylococcus epidermidis Staphylococcus epidermidis - isolation & purification Staphylococcus epidermidis - pathogenicity Staphylococcus epidermidis - physiology Staphylococcus infections Statistical analysis Tetracycline Tetracyclines Virulence Virulence factors Virulence Factors - metabolism |
| title | Bacterial Extracellular DNA Production Is Associated with Outcome of Prosthetic Joint Infections |
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