Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

Mutations in , prevalent in human cancer, are reported to drive tumorigenesis through dominant-negative effects (DNEs) over wild-type TRP53 function as well as neomorphic gain-of-function (GOF) activity. We show that five TRP53 mutants do not accelerate lymphomagenesis on a TRP53-deficient backgroun...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Genes & development 2018-11, Vol.32 (21-22), p.1420-1429
Hauptverfasser:	Aubrey, Brandon J, Janic, Ana, Chen, Yunshun, Chang, Catherine, Lieschke, Elizabeth C, Diepstraten, Sarah T, Kueh, Andrew J, Bernardini, Jonathan P, Dewson, Grant, O'Reilly, Lorraine A, Whitehead, Lachlan, Voss, Anne K, Smyth, Gordon K, Strasser, Andreas, Kelly, Gemma L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis - genetics Lymphoma - genetics Mice Mice, Inbred C57BL Mice, Transgenic Mutation Research Paper Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!