Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti-PD-1 Therapies in Metastatic Melanoma

PD-1/L1 axis-directed therapies produce clinical responses in a subset of patients; therefore, biomarkers of response are needed. We hypothesized that quantifying key immunosuppression mechanisms within the tumor microenvironment by multiparameter algorithms would identify strong predictors of anti-...

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Veröffentlicht in:	Clinical cancer research 2018-11, Vol.24 (21), p.5250-5260
Hauptverfasser:	Johnson, Douglas B, Bordeaux, Jennifer, Kim, Ju Young, Vaupel, Christine, Rimm, David L, Ho, Thai H, Joseph, Richard W, Daud, Adil I, Conry, Robert M, Gaughan, Elizabeth M, Hernandez-Aya, Leonel F, Dimou, Anastasios, Funchain, Pauline, Smithy, James, Witte, John S, McKee, Svetlana B, Ko, Jennifer, Wrangle, John M, Dabbas, Bashar, Tangri, Shabnam, Lameh, Jelveh, Hall, Jeffrey, Markowitz, Joseph, Balko, Justin M, Dakappagari, Naveen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use B7-H1 Antigen - metabolism Biomarkers, Tumor Biopsy Cell Line, Tumor Female HLA-DR Antigens - metabolism Humans Immunohistochemistry Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Male Melanoma - drug therapy Melanoma - metabolism Melanoma - mortality Melanoma - pathology Middle Aged Models, Biological Neoplasm Metastasis Neoplasm Staging Prognosis Programmed Cell Death 1 Receptor - metabolism Protein Binding Retreatment Treatment Outcome
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