Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat ( Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia
Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no eff...
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| Veröffentlicht in: | Nutrients 2018-10, Vol.10 (10), p.1503 |
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| creator | Ninomiya, Kazumi Ina, Shigenobu Hamada, Aya Yamaguchi, Yusuke Akao, Makoto Shinmachi, Fumie Kumagai, Hitoshi Kumagai, Hitomi |
| description | Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes. |
| doi_str_mv | 10.3390/nu10101503 |
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Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10101503</identifier><identifier>PMID: 30326572</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>albumins ; Albumins - isolation & purification ; Albumins - pharmacology ; alpha-amylase ; alpha-Amylases - antagonists & inhibitors ; alpha-Amylases - metabolism ; Animals ; Biomarkers - blood ; blood glucose ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; buckwheat ; diabetes ; enzyme inhibitors ; Fagopyrum - chemistry ; Fagopyrum esculentum ; functional foods ; glucose ; Glycoside Hydrolase Inhibitors - isolation & purification ; Glycoside Hydrolase Inhibitors - pharmacology ; Humans ; hydrolysates ; hydrolysis ; hyperglycemia ; Hyperglycemia - blood ; Hyperglycemia - drug therapy ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - pharmacology ; Insulin - blood ; Male ; mammals ; Plant Proteins - isolation & purification ; Plant Proteins - pharmacology ; Postprandial Period ; Protein Stability ; Rats, Wistar ; starch ; thermal stability ; Triticum - chemistry ; wheat</subject><ispartof>Nutrients, 2018-10, Vol.10 (10), p.1503</ispartof><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-a49fed5aebcfa5047e50aeca888578cdd4c151f0d4eb15e6512a2a07da1dbc753</citedby><cites>FETCH-LOGICAL-c411t-a49fed5aebcfa5047e50aeca888578cdd4c151f0d4eb15e6512a2a07da1dbc753</cites><orcidid>0000-0001-6288-1198 ; 0000-0001-5293-8947</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213359/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213359/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30326572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ninomiya, Kazumi</creatorcontrib><creatorcontrib>Ina, Shigenobu</creatorcontrib><creatorcontrib>Hamada, Aya</creatorcontrib><creatorcontrib>Yamaguchi, Yusuke</creatorcontrib><creatorcontrib>Akao, Makoto</creatorcontrib><creatorcontrib>Shinmachi, Fumie</creatorcontrib><creatorcontrib>Kumagai, Hitoshi</creatorcontrib><creatorcontrib>Kumagai, Hitomi</creatorcontrib><title>Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat ( Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes.</description><subject>albumins</subject><subject>Albumins - isolation & purification</subject><subject>Albumins - pharmacology</subject><subject>alpha-amylase</subject><subject>alpha-Amylases - antagonists & inhibitors</subject><subject>alpha-Amylases - metabolism</subject><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>blood glucose</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>buckwheat</subject><subject>diabetes</subject><subject>enzyme inhibitors</subject><subject>Fagopyrum - chemistry</subject><subject>Fagopyrum esculentum</subject><subject>functional foods</subject><subject>glucose</subject><subject>Glycoside Hydrolase Inhibitors - isolation & purification</subject><subject>Glycoside Hydrolase Inhibitors - pharmacology</subject><subject>Humans</subject><subject>hydrolysates</subject><subject>hydrolysis</subject><subject>hyperglycemia</subject><subject>Hyperglycemia - blood</subject><subject>Hyperglycemia - drug therapy</subject><subject>Hypoglycemic Agents - isolation & purification</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>mammals</subject><subject>Plant Proteins - isolation & purification</subject><subject>Plant Proteins - pharmacology</subject><subject>Postprandial Period</subject><subject>Protein Stability</subject><subject>Rats, Wistar</subject><subject>starch</subject><subject>thermal stability</subject><subject>Triticum - chemistry</subject><subject>wheat</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EolXphgdAXhakgH_iOHeDdFu1tFIRSMDamjjjG0NiBzspypon4kV4JlJaSlkxs5iR5tPRGR1CnnL2UsoNexVmztZWTD4g-4JpUVRVKR_e2_fIYc6f2XVppiv5mOxJJkWltNgn3z_M45gwZ3-F9NQ5tBONjk4d0p8_iu2w9JCRXoTON36KiW77Zh58oC7FgR7P9su3DmGiR_QMdnFc0jxQzHbuMUzr-jZisN1zGgN9H_M0Jgith56eLyOmXb9YwMHDE_LIQZ_x8HYekE9npx9PzovLd28uTraXhS05nwooNw5bBdhYB4qVGhUDtFDXtdK1bdvScsUda0tsuMJKcQECmG6Bt43VSh6Q1ze649wM2NrVY4LejMkPkBYTwZt_L8F3ZhevTCW4lGqzChzdCqT4dcY8mcFni30PAeOcjRB1tRFKafl_lAte1rr8bevFDWpTzDmhu3PEmbnO2PzNeIWf3f_hDv2TqPwFPnOlpQ</recordid><startdate>20181015</startdate><enddate>20181015</enddate><creator>Ninomiya, Kazumi</creator><creator>Ina, Shigenobu</creator><creator>Hamada, Aya</creator><creator>Yamaguchi, Yusuke</creator><creator>Akao, Makoto</creator><creator>Shinmachi, Fumie</creator><creator>Kumagai, Hitoshi</creator><creator>Kumagai, Hitomi</creator><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6288-1198</orcidid><orcidid>https://orcid.org/0000-0001-5293-8947</orcidid></search><sort><creationdate>20181015</creationdate><title>Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat ( Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia</title><author>Ninomiya, Kazumi ; Ina, Shigenobu ; Hamada, Aya ; Yamaguchi, Yusuke ; Akao, Makoto ; Shinmachi, Fumie ; Kumagai, Hitoshi ; Kumagai, Hitomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-a49fed5aebcfa5047e50aeca888578cdd4c151f0d4eb15e6512a2a07da1dbc753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>albumins</topic><topic>Albumins - isolation & purification</topic><topic>Albumins - pharmacology</topic><topic>alpha-amylase</topic><topic>alpha-Amylases - antagonists & inhibitors</topic><topic>alpha-Amylases - metabolism</topic><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>blood glucose</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>buckwheat</topic><topic>diabetes</topic><topic>enzyme inhibitors</topic><topic>Fagopyrum - chemistry</topic><topic>Fagopyrum esculentum</topic><topic>functional foods</topic><topic>glucose</topic><topic>Glycoside Hydrolase Inhibitors - isolation & purification</topic><topic>Glycoside Hydrolase Inhibitors - pharmacology</topic><topic>Humans</topic><topic>hydrolysates</topic><topic>hydrolysis</topic><topic>hyperglycemia</topic><topic>Hyperglycemia - blood</topic><topic>Hyperglycemia - drug therapy</topic><topic>Hypoglycemic Agents - isolation & purification</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>mammals</topic><topic>Plant Proteins - isolation & purification</topic><topic>Plant Proteins - pharmacology</topic><topic>Postprandial Period</topic><topic>Protein Stability</topic><topic>Rats, Wistar</topic><topic>starch</topic><topic>thermal stability</topic><topic>Triticum - chemistry</topic><topic>wheat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ninomiya, Kazumi</creatorcontrib><creatorcontrib>Ina, Shigenobu</creatorcontrib><creatorcontrib>Hamada, Aya</creatorcontrib><creatorcontrib>Yamaguchi, Yusuke</creatorcontrib><creatorcontrib>Akao, Makoto</creatorcontrib><creatorcontrib>Shinmachi, Fumie</creatorcontrib><creatorcontrib>Kumagai, Hitoshi</creatorcontrib><creatorcontrib>Kumagai, Hitomi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ninomiya, Kazumi</au><au>Ina, Shigenobu</au><au>Hamada, Aya</au><au>Yamaguchi, Yusuke</au><au>Akao, Makoto</au><au>Shinmachi, Fumie</au><au>Kumagai, Hitoshi</au><au>Kumagai, Hitomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat ( Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2018-10-15</date><risdate>2018</risdate><volume>10</volume><issue>10</issue><spage>1503</spage><pages>1503-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>30326572</pmid><doi>10.3390/nu10101503</doi><orcidid>https://orcid.org/0000-0001-6288-1198</orcidid><orcidid>https://orcid.org/0000-0001-5293-8947</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | albumins Albumins - isolation & purification Albumins - pharmacology alpha-amylase alpha-Amylases - antagonists & inhibitors alpha-Amylases - metabolism Animals Biomarkers - blood blood glucose Blood Glucose - drug effects Blood Glucose - metabolism buckwheat diabetes enzyme inhibitors Fagopyrum - chemistry Fagopyrum esculentum functional foods glucose Glycoside Hydrolase Inhibitors - isolation & purification Glycoside Hydrolase Inhibitors - pharmacology Humans hydrolysates hydrolysis hyperglycemia Hyperglycemia - blood Hyperglycemia - drug therapy Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Insulin - blood Male mammals Plant Proteins - isolation & purification Plant Proteins - pharmacology Postprandial Period Protein Stability Rats, Wistar starch thermal stability Triticum - chemistry wheat |
| title | Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat ( Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia |
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