Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study
There have been increases in the incidence of obesity in Lebanon over the past few decades. Fatty acid intake and metabolism have been postulated to influence obesity, but few epidemiological studies have been conducted. The aim of this study was to investigate the correlation between serum fatty ac...
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| Veröffentlicht in: | Nutrients 2018-09, Vol.10 (10), p.1371 |
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| creator | Yammine, Sahar G Naja, Farah Tamim, Hani Nasrallah, Mona Biessy, Carine Aglago, Elom K Matta, Michèle Romieu, Isabelle Gunter, Marc J Nasreddine, Lara Chajès, Véronique |
| description | There have been increases in the incidence of obesity in Lebanon over the past few decades. Fatty acid intake and metabolism have been postulated to influence obesity, but few epidemiological studies have been conducted. The aim of this study was to investigate the correlation between serum fatty acid levels and indicators of obesity in a cross-sectional study nested within a cohort of 501 Lebanese adults residing in Greater Beirut. A total of 395 available serum samples (129 men, 266 women) were profiled for phospholipid fatty acid composition. Spearman correlation coefficients adjusted for relevant confounders and corrected for multiple testing were calculated between serum fatty acids, desaturation indices, and indicators of adiposity (body mass index (BMI) and waist). BMI was significantly positively correlated with saturated fatty acids in men (r = 0.40,
< 0.0001, q < 0.0001) and women (r = 0.33,
< 0.0001, q < 0.0001). BMI was significantly positively correlated with monounsaturated fatty acid palmitoleic acid in women (r = 0.15,
= 0.01, q = 0.03). This study suggests that high blood levels of some saturated fatty acids and the monounsaturated fatty acid palmitoleic acid, likely derived from both dietary intakes of saturated fatty acids and endogenous lipogenesis, may have been associated with adiposity in the Lebanese population. The causality of these associations needs to be explored in experimental settings. |
| doi_str_mv | 10.3390/nu10101371 |
| format | Article |
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< 0.0001, q < 0.0001) and women (r = 0.33,
< 0.0001, q < 0.0001). BMI was significantly positively correlated with monounsaturated fatty acid palmitoleic acid in women (r = 0.15,
= 0.01, q = 0.03). This study suggests that high blood levels of some saturated fatty acids and the monounsaturated fatty acid palmitoleic acid, likely derived from both dietary intakes of saturated fatty acids and endogenous lipogenesis, may have been associated with adiposity in the Lebanese population. The causality of these associations needs to be explored in experimental settings.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10101371</identifier><identifier>PMID: 30257485</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>adiposity ; Adiposity - physiology ; Adult ; adults ; blood serum ; Body Mass Index ; Cross-Sectional Studies ; Dietary Fats - blood ; epidemiological studies ; fatty acid composition ; Fatty Acids, Monounsaturated - blood ; Female ; food intake ; Humans ; Incidence ; Lebanon ; Lebanon - epidemiology ; lipogenesis ; Lipogenesis - physiology ; Male ; men ; Middle Aged ; obesity ; Obesity - blood ; Obesity - epidemiology ; palmitoleic acid ; phospholipid fatty acids ; Phospholipids - blood ; saturated fatty acids ; waist ; Waist Circumference ; women</subject><ispartof>Nutrients, 2018-09, Vol.10 (10), p.1371</ispartof><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-b6c1f7b134733f7b6cdc40be5032d5cddc7f9f0fd0bac426ae606728bfdd13f23</citedby><cites>FETCH-LOGICAL-c411t-b6c1f7b134733f7b6cdc40be5032d5cddc7f9f0fd0bac426ae606728bfdd13f23</cites><orcidid>0000-0003-1297-3064 ; 0000-0003-0880-3513</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213065/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213065/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30257485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yammine, Sahar G</creatorcontrib><creatorcontrib>Naja, Farah</creatorcontrib><creatorcontrib>Tamim, Hani</creatorcontrib><creatorcontrib>Nasrallah, Mona</creatorcontrib><creatorcontrib>Biessy, Carine</creatorcontrib><creatorcontrib>Aglago, Elom K</creatorcontrib><creatorcontrib>Matta, Michèle</creatorcontrib><creatorcontrib>Romieu, Isabelle</creatorcontrib><creatorcontrib>Gunter, Marc J</creatorcontrib><creatorcontrib>Nasreddine, Lara</creatorcontrib><creatorcontrib>Chajès, Véronique</creatorcontrib><title>Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>There have been increases in the incidence of obesity in Lebanon over the past few decades. Fatty acid intake and metabolism have been postulated to influence obesity, but few epidemiological studies have been conducted. The aim of this study was to investigate the correlation between serum fatty acid levels and indicators of obesity in a cross-sectional study nested within a cohort of 501 Lebanese adults residing in Greater Beirut. A total of 395 available serum samples (129 men, 266 women) were profiled for phospholipid fatty acid composition. Spearman correlation coefficients adjusted for relevant confounders and corrected for multiple testing were calculated between serum fatty acids, desaturation indices, and indicators of adiposity (body mass index (BMI) and waist). BMI was significantly positively correlated with saturated fatty acids in men (r = 0.40,
< 0.0001, q < 0.0001) and women (r = 0.33,
< 0.0001, q < 0.0001). BMI was significantly positively correlated with monounsaturated fatty acid palmitoleic acid in women (r = 0.15,
= 0.01, q = 0.03). This study suggests that high blood levels of some saturated fatty acids and the monounsaturated fatty acid palmitoleic acid, likely derived from both dietary intakes of saturated fatty acids and endogenous lipogenesis, may have been associated with adiposity in the Lebanese population. The causality of these associations needs to be explored in experimental settings.</description><subject>adiposity</subject><subject>Adiposity - physiology</subject><subject>Adult</subject><subject>adults</subject><subject>blood serum</subject><subject>Body Mass Index</subject><subject>Cross-Sectional Studies</subject><subject>Dietary Fats - blood</subject><subject>epidemiological studies</subject><subject>fatty acid composition</subject><subject>Fatty Acids, Monounsaturated - blood</subject><subject>Female</subject><subject>food intake</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lebanon</subject><subject>Lebanon - epidemiology</subject><subject>lipogenesis</subject><subject>Lipogenesis - physiology</subject><subject>Male</subject><subject>men</subject><subject>Middle Aged</subject><subject>obesity</subject><subject>Obesity - blood</subject><subject>Obesity - epidemiology</subject><subject>palmitoleic acid</subject><subject>phospholipid fatty acids</subject><subject>Phospholipids - blood</subject><subject>saturated fatty acids</subject><subject>waist</subject><subject>Waist Circumference</subject><subject>women</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFq3DAQFSWlCWku-YCiYwi4lTS2tJtDwSxJW1hIYJOzkKVxVsW2XEtO2L-PlqRpesrMYR68xxuNHiGnnH0FWLJvw8xZblD8AzkSTIlCyhIO3uBDchLjb7YvxZSET-QQmKhUuaiOyFzHGKw3yYeBNpgeEQe6wWnu6c02xHEbOj96R69MSjta2wzX-IBdpGZwtHZ-DNFnxvRhuM9UYwaMmIm5S_GC1nQ1hRiLDdr9BtPRTZrd7jP52Jou4snLPCZ3V5e3q5_F-vrHr1W9LmzJeSoaaXmrGg6lAshAWmdL1mDFQLjKOmdVu2xZ61hjbCmkQcmkEoumdY5DK-CYfH_2HeemR2dxSJPp9Dj53kw7HYzX_zOD3-r78KCl4MBklQ3OXgym8GfGmHTvo8Wuy2eGOWohFnIpqlzvSzkHsYCygiw9f5ba_edM2L6-iDO9T1X_SzWLv7y94VX6N0N4AkJxnxc</recordid><startdate>20180925</startdate><enddate>20180925</enddate><creator>Yammine, Sahar G</creator><creator>Naja, Farah</creator><creator>Tamim, Hani</creator><creator>Nasrallah, Mona</creator><creator>Biessy, Carine</creator><creator>Aglago, Elom K</creator><creator>Matta, Michèle</creator><creator>Romieu, Isabelle</creator><creator>Gunter, Marc J</creator><creator>Nasreddine, Lara</creator><creator>Chajès, Véronique</creator><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1297-3064</orcidid><orcidid>https://orcid.org/0000-0003-0880-3513</orcidid></search><sort><creationdate>20180925</creationdate><title>Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study</title><author>Yammine, Sahar G ; Naja, Farah ; Tamim, Hani ; Nasrallah, Mona ; Biessy, Carine ; Aglago, Elom K ; Matta, Michèle ; Romieu, Isabelle ; Gunter, Marc J ; Nasreddine, Lara ; Chajès, Véronique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-b6c1f7b134733f7b6cdc40be5032d5cddc7f9f0fd0bac426ae606728bfdd13f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>adiposity</topic><topic>Adiposity - physiology</topic><topic>Adult</topic><topic>adults</topic><topic>blood serum</topic><topic>Body Mass Index</topic><topic>Cross-Sectional Studies</topic><topic>Dietary Fats - blood</topic><topic>epidemiological studies</topic><topic>fatty acid composition</topic><topic>Fatty Acids, Monounsaturated - blood</topic><topic>Female</topic><topic>food intake</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lebanon</topic><topic>Lebanon - epidemiology</topic><topic>lipogenesis</topic><topic>Lipogenesis - physiology</topic><topic>Male</topic><topic>men</topic><topic>Middle Aged</topic><topic>obesity</topic><topic>Obesity - blood</topic><topic>Obesity - epidemiology</topic><topic>palmitoleic acid</topic><topic>phospholipid fatty acids</topic><topic>Phospholipids - blood</topic><topic>saturated fatty acids</topic><topic>waist</topic><topic>Waist Circumference</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yammine, Sahar G</creatorcontrib><creatorcontrib>Naja, Farah</creatorcontrib><creatorcontrib>Tamim, Hani</creatorcontrib><creatorcontrib>Nasrallah, Mona</creatorcontrib><creatorcontrib>Biessy, Carine</creatorcontrib><creatorcontrib>Aglago, Elom K</creatorcontrib><creatorcontrib>Matta, Michèle</creatorcontrib><creatorcontrib>Romieu, Isabelle</creatorcontrib><creatorcontrib>Gunter, Marc J</creatorcontrib><creatorcontrib>Nasreddine, Lara</creatorcontrib><creatorcontrib>Chajès, Véronique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yammine, Sahar G</au><au>Naja, Farah</au><au>Tamim, Hani</au><au>Nasrallah, Mona</au><au>Biessy, Carine</au><au>Aglago, Elom K</au><au>Matta, Michèle</au><au>Romieu, Isabelle</au><au>Gunter, Marc J</au><au>Nasreddine, Lara</au><au>Chajès, Véronique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2018-09-25</date><risdate>2018</risdate><volume>10</volume><issue>10</issue><spage>1371</spage><pages>1371-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>There have been increases in the incidence of obesity in Lebanon over the past few decades. Fatty acid intake and metabolism have been postulated to influence obesity, but few epidemiological studies have been conducted. The aim of this study was to investigate the correlation between serum fatty acid levels and indicators of obesity in a cross-sectional study nested within a cohort of 501 Lebanese adults residing in Greater Beirut. A total of 395 available serum samples (129 men, 266 women) were profiled for phospholipid fatty acid composition. Spearman correlation coefficients adjusted for relevant confounders and corrected for multiple testing were calculated between serum fatty acids, desaturation indices, and indicators of adiposity (body mass index (BMI) and waist). BMI was significantly positively correlated with saturated fatty acids in men (r = 0.40,
< 0.0001, q < 0.0001) and women (r = 0.33,
< 0.0001, q < 0.0001). BMI was significantly positively correlated with monounsaturated fatty acid palmitoleic acid in women (r = 0.15,
= 0.01, q = 0.03). This study suggests that high blood levels of some saturated fatty acids and the monounsaturated fatty acid palmitoleic acid, likely derived from both dietary intakes of saturated fatty acids and endogenous lipogenesis, may have been associated with adiposity in the Lebanese population. The causality of these associations needs to be explored in experimental settings.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>30257485</pmid><doi>10.3390/nu10101371</doi><orcidid>https://orcid.org/0000-0003-1297-3064</orcidid><orcidid>https://orcid.org/0000-0003-0880-3513</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | adiposity Adiposity - physiology Adult adults blood serum Body Mass Index Cross-Sectional Studies Dietary Fats - blood epidemiological studies fatty acid composition Fatty Acids, Monounsaturated - blood Female food intake Humans Incidence Lebanon Lebanon - epidemiology lipogenesis Lipogenesis - physiology Male men Middle Aged obesity Obesity - blood Obesity - epidemiology palmitoleic acid phospholipid fatty acids Phospholipids - blood saturated fatty acids waist Waist Circumference women |
| title | Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study |
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