Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury

Alveolar epithelial dysfunction induced by hypoxic stress plays a significant role in the pathological process of lung ischemia-reperfusion injury (IRI). Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in exerting protective immunomodulatory effects, thereby reducing airway inflamma...

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Veröffentlicht in:	International journal of molecular sciences 2018-09, Vol.19 (10), p.2996
Hauptverfasser:	Shologu, Nala, Scully, Michael, Laffey, John G, O'Toole, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Animals Anti-Inflammatory Agents - pharmacology Apoptosis Bone Marrow Cells - cytology Cell Survival - drug effects Culture Media, Conditioned - pharmacology Cytoprotection Epithelium - pathology HSP70 Heat-Shock Proteins - metabolism Humans Hypoxia - complications Immunomodulation Lung Injury - etiology Lung Injury - pathology Lung Injury - therapy Male Matrix Metalloproteinases - metabolism Membrane Proteins - metabolism Mesenchymal Stem Cells - metabolism Protective Agents Proteome - metabolism Rats, Sprague-Dawley
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