Codon-specific effects of tRNA anticodon loop modifications on translational misreading errors in the yeast Saccharomyces cerevisiae

Abstract Protein synthesis requires both high speed and accuracy to ensure a healthy cellular environment. Estimates of errors during protein synthesis in Saccharomyces cerevisiae have varied from 10−3 to 10−4 errors per codon. Here, we show that errors made by ${\rm{tRNA}}^{\rm Glu}_{\rm UUC}$ in y...

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Veröffentlicht in:	Nucleic acids research 2018-11, Vol.46 (19), p.10331-10339
Hauptverfasser:	Joshi, Kartikeya, Bhatt, Monika J, Farabaugh, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticodon - genetics Codon - genetics Genetic Code Glutamine - genetics Protein Biosynthesis Protein Processing, Post-Translational - genetics RNA and RNA-protein complexes RNA Processing, Post-Transcriptional - genetics RNA, Transfer - genetics Saccharomyces cerevisiae - genetics Uridine - genetics
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